TY  - JOUR
AU  - Li, Xinjun
AU  - Thomsen, Hauke
AU  - Sundquist, Kristina
AU  - Sundquist, Jan
AU  - Försti, Asta
AU  - Hemminki, Kari
TI  - Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden.
JO  - Autoimmune diseases
VL  - 2021
SN  - 2090-0430
CY  - London [u.a.]
PB  - Sage-Hindawi
M1  - DKFZ-2021-00222
SP  - 8815297
PY  - 2021
N1  - #LA:C050# /  2021 Jan 12;2021:8815297
AB  - Pernicious anemia (PA) is an autoimmune disease (AID) which is caused by lack of vitamin B12 (cobalamin) due to its impaired uptake. PA is a multifactorial disease which is associated with a number of other AID comorbidities and which is manifested as part of autoimmune polyglandular syndrome. Due to the shortage of family studies on PA, we planned to address the problem by assessing familial risks for concordant PA between family members and for discordant PA in families of other AID patients.We collected data on patients diagnosed with AIDs from the Swedish hospitals and family data from a population register. We calculated standardized incidence ratios (SIRs) in families for concordant and discordant risks.The number of PA patients in the offspring generation (for which the familial risk was calculated) was 7701; 278 (3.6
LB  - PUB:(DE-HGF)16
C6  - pmid:33505716
C2  - pmc:PMC7815416
DO  - DOI:10.1155/2021/8815297
UR  - https://inrepo02.dkfz.de/record/167249
ER  -