000167254 001__ 167254
000167254 005__ 20240229133534.0
000167254 0247_ $$2doi$$a10.1038/s41598-021-81902-4
000167254 0247_ $$2pmid$$apmid:33504885
000167254 0247_ $$2altmetric$$aaltmetric:99093583
000167254 037__ $$aDKFZ-2021-00227
000167254 041__ $$aeng
000167254 082__ $$a600
000167254 1001_ $$0P:(DE-He78)628d5ea4d1b87c9ee351782af809119d$$aMüller, Jana$$b0$$eFirst author$$udkfz
000167254 245__ $$aChemotherapy-induced peripheral neuropathy: longitudinal analysis of predictors for postural control.
000167254 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2021
000167254 3367_ $$2DRIVER$$aarticle
000167254 3367_ $$2DataCite$$aOutput Types/Journal article
000167254 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1637310508_26656
000167254 3367_ $$2BibTeX$$aARTICLE
000167254 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000167254 3367_ $$00$$2EndNote$$aJournal Article
000167254 500__ $$a#EA:D120##EA:C110 !!
000167254 520__ $$aImpaired postural control is often observed in response to neurotoxic chemotherapy. However, potential explanatory factors other than chemotherapy-induced peripheral neuropathy (CIPN) have not been adequately considered to date due to primarily cross-sectional study designs. Our objective was to comprehensively analyze postural control during and after neurotoxic chemotherapy, and to identify potential CIPN-independent predictors for its impairment. Postural control and CIPN symptoms (EORTC QLQ-CIPN20) were longitudinally assessed before, during and three weeks after neurotoxic chemotherapy, and in three and six months follow-up examinations (N = 54). The influence of peripheral nerve function as determined by nerve conduction studies (NCS: compound motor action potentials (CMAP) and sensory action potentials (SNAP)), physical activity, and muscle strength on the change in postural control during and after chemotherapy was analyzed by multiple linear regression adjusted for age and body mass index. Postural control, CIPN signs/symptoms, and CMAP/SNAP amplitudes significantly deteriorated during chemotherapy (p < .01). During follow-up, patients recovered from postural instabilities (p < .01), whereas CIPN signs/symptoms and pathologic NCS findings persisted compared to baseline (p < .001). The regression model showed that low CMAP and high SNAP amplitudes at baseline predicted impairment of postural control during but not after chemotherapy. Hence, pre-therapeutically disturbed somatosensory inputs may induce adaptive processes that have compensatory effects and allow recovery of postural control while CIPN signs/symptoms and pathologic peripheral nerve function persist. Baseline NCS findings in cancer patients who receive neurotoxic chemotherapy thus might assist in delineating individual CIPN risk profiles more precisely to which specific exercise intervention programs could be tailor-made.
000167254 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000167254 588__ $$aDataset connected to CrossRef, PubMed,
000167254 7001_ $$0P:(DE-He78)e0edc48464c2d5afd09687075ebd532b$$aKreutz, Charlotte$$b1$$udkfz
000167254 7001_ $$00000-0003-1823-1037$$aRinghof, Steffen$$b2
000167254 7001_ $$00000-0003-0683-8915$$aKoeppel, Maximilian$$b3
000167254 7001_ $$00000-0002-1696-2488$$aKleindienst, Nikolaus$$b4
000167254 7001_ $$00000-0003-0255-1722$$aSam, Georges$$b5
000167254 7001_ $$aSchneeweiss, Andreas$$b6
000167254 7001_ $$aWiskemann, Joachim$$b7
000167254 7001_ $$aWeiler, Markus$$b8
000167254 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-021-81902-4$$gVol. 11, no. 1, p. 2398$$n1$$p2398$$tScientific reports$$v11$$x2045-2322$$y2021
000167254 909CO $$ooai:inrepo02.dkfz.de:167254$$pVDB
000167254 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)628d5ea4d1b87c9ee351782af809119d$$aDeutsches Krebsforschungszentrum$$b0$$kDKFZ
000167254 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)e0edc48464c2d5afd09687075ebd532b$$aDeutsches Krebsforschungszentrum$$b1$$kDKFZ
000167254 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000167254 9130_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000167254 9141_ $$y2021
000167254 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bSCI REP-UK : 2018$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review$$d2020-08-29
000167254 915__ $$0LIC:(DE-HGF)CCBYNV$$2V:(DE-HGF)$$aCreative Commons Attribution CC BY (No Version)$$bDOAJ$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0561$$2StatID$$aArticle Processing Charges$$d2020-08-29
000167254 915__ $$0StatID:(DE-HGF)0700$$2StatID$$aFees$$d2020-08-29
000167254 9201_ $$0I:(DE-He78)C110-20160331$$kC110$$lBewegung, Präventionsforschung und Krebs$$x0
000167254 9201_ $$0I:(DE-He78)D120-20160331$$kD120$$lD120 Angewandte Tumor-Immunität$$x1
000167254 980__ $$ajournal
000167254 980__ $$aVDB
000167254 980__ $$aI:(DE-He78)C110-20160331
000167254 980__ $$aI:(DE-He78)D120-20160331
000167254 980__ $$aUNRESTRICTED