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@ARTICLE{Mller:167254,
      author       = {J. Müller$^*$ and C. Kreutz$^*$ and S. Ringhof and M.
                      Koeppel and N. Kleindienst and G. Sam and A. Schneeweiss and
                      J. Wiskemann and M. Weiler},
      title        = {{C}hemotherapy-induced peripheral neuropathy: longitudinal
                      analysis of predictors for postural control.},
      journal      = {Scientific reports},
      volume       = {11},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DKFZ-2021-00227},
      pages        = {2398},
      year         = {2021},
      note         = {#EA:D120##EA:C110 !!},
      abstract     = {Impaired postural control is often observed in response to
                      neurotoxic chemotherapy. However, potential explanatory
                      factors other than chemotherapy-induced peripheral
                      neuropathy (CIPN) have not been adequately considered to
                      date due to primarily cross-sectional study designs. Our
                      objective was to comprehensively analyze postural control
                      during and after neurotoxic chemotherapy, and to identify
                      potential CIPN-independent predictors for its impairment.
                      Postural control and CIPN symptoms (EORTC QLQ-CIPN20) were
                      longitudinally assessed before, during and three weeks after
                      neurotoxic chemotherapy, and in three and six months
                      follow-up examinations (N = 54). The influence of peripheral
                      nerve function as determined by nerve conduction studies
                      (NCS: compound motor action potentials (CMAP) and sensory
                      action potentials (SNAP)), physical activity, and muscle
                      strength on the change in postural control during and after
                      chemotherapy was analyzed by multiple linear regression
                      adjusted for age and body mass index. Postural control, CIPN
                      signs/symptoms, and CMAP/SNAP amplitudes significantly
                      deteriorated during chemotherapy (p < .01). During
                      follow-up, patients recovered from postural instabilities (p
                      < .01), whereas CIPN signs/symptoms and pathologic NCS
                      findings persisted compared to baseline (p < .001). The
                      regression model showed that low CMAP and high SNAP
                      amplitudes at baseline predicted impairment of postural
                      control during but not after chemotherapy. Hence,
                      pre-therapeutically disturbed somatosensory inputs may
                      induce adaptive processes that have compensatory effects and
                      allow recovery of postural control while CIPN signs/symptoms
                      and pathologic peripheral nerve function persist. Baseline
                      NCS findings in cancer patients who receive neurotoxic
                      chemotherapy thus might assist in delineating individual
                      CIPN risk profiles more precisely to which specific exercise
                      intervention programs could be tailor-made.},
      cin          = {C110 / D120},
      ddc          = {600},
      cid          = {I:(DE-He78)C110-20160331 / I:(DE-He78)D120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33504885},
      doi          = {10.1038/s41598-021-81902-4},
      url          = {https://inrepo02.dkfz.de/record/167254},
}