% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Amitay:167279,
      author       = {E. Amitay$^*$ and P. R. Carr$^*$ and A. Gies$^*$ and D. C.
                      Laetsch$^*$ and H. Brenner$^*$},
      title        = {{P}robiotic/{S}ynbiotic {T}reatment and {P}ostoperative
                      {C}omplications in {C}olorectal {C}ancer {P}atients:
                      {S}ystematic {R}eview and {M}eta-analysis of {R}andomized
                      {C}ontrolled {T}rials.},
      journal      = {Clinical and translational gastroenterology},
      volume       = {11},
      number       = {12},
      issn         = {2155-384X},
      address      = {London},
      publisher    = {Nature Publ. Group},
      reportid     = {DKFZ-2021-00234},
      pages        = {e00268},
      year         = {2020},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Colorectal cancer (CRC) is a leading cause of morbidity and
                      mortality. Post-CRC resection complications and lower
                      quality of life (QoL) are associated with a lower long-term
                      survival. Perioperative administration of
                      probiotics/synbiotics might lower prevalence of side effects
                      and improve QoL and survival among CRC patients. Medline,
                      Web of Science, Cochrane database, Embase, and clinical
                      trials registries were searched in January 2020. Altogether,
                      16 randomized placebo-controlled probiotic/synbiotic
                      clinical trials that included patients undergoing CRC
                      surgery and investigated postoperative complications and QoL
                      side effects were found. Meta-analyses using random-effects
                      model were performed on data from 11 studies to calculate
                      the effects of probiotics/synbiotics on common CRC resection
                      postoperative side effects and complications. Perioperative
                      probiotics/synbiotics administration was associated with
                      lower infection incidence (odds ratio [OR] = 0.34, P <
                      0.001), lower diarrheal incidence (OR = 0.38, P < 0.001),
                      faster return to normal gut function (mean difference [MD]
                      -0.66 days, P < 0.001), shorter postoperative antibiotics
                      use (MD -0.64 days, P < 0.001), lower incidence of
                      septicemia (OR = 0.31, P < 0.001), and shorter length of
                      hospital stay (MD -0.41 days, P = 0.110). The results
                      support the hypothesis that short-term perioperative
                      administration of probiotics/synbiotics, which are easy to
                      administer, have few side-effects, and are low cost compared
                      with alternatives, might help to alleviate gastrointestinal
                      symptoms and postoperative complications among CRC
                      patients.},
      subtyp        = {Review Article},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33512803},
      pmc          = {pmc:PMC7714058},
      doi          = {10.14309/ctg.0000000000000268},
      url          = {https://inrepo02.dkfz.de/record/167279},
}