TY  - JOUR
AU  - Paredes, Isidora
AU  - Vieira, José Ricardo
AU  - Shah, Bhavin
AU  - Ramunno, Carla F
AU  - Dyckow, Julia
AU  - Adler, Heike
AU  - Richter, Melanie
AU  - Schermann, Geza
AU  - Giannakouri, Evangelia
AU  - Schirmer, Lucas
AU  - Augustin, Hellmut G
AU  - Ruiz de Almodóvar, Carmen
TI  - Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk.
JO  - Nature neuroscience
VL  - 24
IS  - 4
SN  - 1546-1726
CY  - New York, NY
PB  - Nature America
M1  - DKFZ-2021-00237
SP  - 478-488
PY  - 2021
N1  - DKFZ-ZMBH Alliance / 2021 Apr;24(4):478-488
AB  - Neural-derived signals are crucial regulators of CNS vascularization. However, whether the vasculature responds to these signals by means of elongating and branching or in addition by building a feedback response to modulate neurodevelopmental processes remains unknown. In this study, we identified bidirectional crosstalk between the neural and the vascular compartment of the developing CNS required for oligodendrocyte precursor cell specification. Mechanistically, we show that neural progenitor cells (NPCs) express angiopoietin-1 (Ang1) and that this expression is regulated by Sonic hedgehog. We demonstrate that NPC-derived Ang1 signals to its receptor, Tie2, on endothelial cells to induce the production of transforming growth factor beta 1 (TGFβ1). Endothelial-derived TGFβ1, in turn, acts as an angiocrine molecule and signals back to NPCs to induce their commitment toward oligodendrocyte precursor cells. This work demonstrates a true bidirectional collaboration between NPCs and the vasculature as a critical regulator of oligodendrogenesis.
LB  - PUB:(DE-HGF)16
C6  - pmid:33510480
DO  - DOI:10.1038/s41593-020-00788-z
UR  - https://inrepo02.dkfz.de/record/167282
ER  -