% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Paredes:167282,
      author       = {I. Paredes and J. R. Vieira and B. Shah and C. F. Ramunno
                      and J. Dyckow and H. Adler and M. Richter and G. Schermann
                      and E. Giannakouri$^*$ and L. Schirmer and H. G.
                      Augustin$^*$ and C. Ruiz de Almodóvar},
      title        = {{O}ligodendrocyte precursor cell specification is regulated
                      by bidirectional neural progenitor-endothelial cell
                      crosstalk.},
      journal      = {Nature neuroscience},
      volume       = {24},
      number       = {4},
      issn         = {1546-1726},
      address      = {New York, NY},
      publisher    = {Nature America},
      reportid     = {DKFZ-2021-00237},
      pages        = {478-488},
      year         = {2021},
      note         = {DKFZ-ZMBH Alliance / 2021 Apr;24(4):478-488},
      abstract     = {Neural-derived signals are crucial regulators of CNS
                      vascularization. However, whether the vasculature responds
                      to these signals by means of elongating and branching or in
                      addition by building a feedback response to modulate
                      neurodevelopmental processes remains unknown. In this study,
                      we identified bidirectional crosstalk between the neural and
                      the vascular compartment of the developing CNS required for
                      oligodendrocyte precursor cell specification.
                      Mechanistically, we show that neural progenitor cells (NPCs)
                      express angiopoietin-1 (Ang1) and that this expression is
                      regulated by Sonic hedgehog. We demonstrate that NPC-derived
                      Ang1 signals to its receptor, Tie2, on endothelial cells to
                      induce the production of transforming growth factor beta 1
                      (TGFβ1). Endothelial-derived TGFβ1, in turn, acts as an
                      angiocrine molecule and signals back to NPCs to induce their
                      commitment toward oligodendrocyte precursor cells. This work
                      demonstrates a true bidirectional collaboration between NPCs
                      and the vasculature as a critical regulator of
                      oligodendrogenesis.},
      cin          = {A190},
      ddc          = {610},
      cid          = {I:(DE-He78)A190-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33510480},
      doi          = {10.1038/s41593-020-00788-z},
      url          = {https://inrepo02.dkfz.de/record/167282},
}