%0 Journal Article
%A Dai, Hao
%A Penack, Olaf
%A Radujkovic, Aleksandar
%A Schult, David
%A Majer-Lauterbach, Joshua
%A Blau, Igor Wolfgang
%A Bullinger, Lars
%A Jiang, Sihe
%A Müller-Tidow, Carsten
%A Dreger, Peter
%A Luft, Thomas
%T Early bilirubinemia after allogeneic stem cell transplantation-an endothelial complication.
%J Bone marrow transplantation
%V 56
%N 7
%@ 0268-3369
%C London
%I Nature Publishing Group55086
%M DKFZ-2021-00242
%P 1573-1583
%D 2021
%Z #EA:C020# / 2021 Jul;56(7):1573-1583
%X Hyperbilirubinemia occurs frequently after allogeneic stem cell transplantation. Causes include primary liver damage and endothelial complications as major contributors. Here, we have investigated the impact of early bilirubinemia (EB) on posttransplant outcomes. Maximum total bilirubin levels (days 0-28) were categorized using maximally selected log rank statistics to identify a cut off for the endpoint non-relapse mortality (NRM) in a training cohort of 873 patients. EB above this cut off was correlated with NRM and overall survival (OS) and with pre- and posttransplant Angiopoietin-2, interleukin (IL)18, CXCL8 and suppressor of tumorigenicity-2 (ST2) serum levels, and the endothelial activation and stress index (EASIX). Clinical correlations were validated in a sample of 388 patients transplanted in an independent institution. The EB cut off was determined at 3.6 mg/dL (61.6 µM). EB predicted OS (HR 1.60, 95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33517355
%R 10.1038/s41409-020-01186-6
%U https://inrepo02.dkfz.de/record/167287