TY  - JOUR
AU  - Dai, Hao
AU  - Penack, Olaf
AU  - Radujkovic, Aleksandar
AU  - Schult, David
AU  - Majer-Lauterbach, Joshua
AU  - Blau, Igor Wolfgang
AU  - Bullinger, Lars
AU  - Jiang, Sihe
AU  - Müller-Tidow, Carsten
AU  - Dreger, Peter
AU  - Luft, Thomas
TI  - Early bilirubinemia after allogeneic stem cell transplantation-an endothelial complication.
JO  - Bone marrow transplantation
VL  - 56
IS  - 7
SN  - 0268-3369
CY  - London
PB  - Nature Publishing Group55086
M1  - DKFZ-2021-00242
SP  - 1573-1583
PY  - 2021
N1  - #EA:C020# / 2021 Jul;56(7):1573-1583
AB  - Hyperbilirubinemia occurs frequently after allogeneic stem cell transplantation. Causes include primary liver damage and endothelial complications as major contributors. Here, we have investigated the impact of early bilirubinemia (EB) on posttransplant outcomes. Maximum total bilirubin levels (days 0-28) were categorized using maximally selected log rank statistics to identify a cut off for the endpoint non-relapse mortality (NRM) in a training cohort of 873 patients. EB above this cut off was correlated with NRM and overall survival (OS) and with pre- and posttransplant Angiopoietin-2, interleukin (IL)18, CXCL8 and suppressor of tumorigenicity-2 (ST2) serum levels, and the endothelial activation and stress index (EASIX). Clinical correlations were validated in a sample of 388 patients transplanted in an independent institution. The EB cut off was determined at 3.6 mg/dL (61.6 µM). EB predicted OS (HR 1.60, 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33517355
DO  - DOI:10.1038/s41409-020-01186-6
UR  - https://inrepo02.dkfz.de/record/167287
ER  -