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@ARTICLE{Klika:167329,
      author       = {K. Klika$^*$ and C. Da Pieve and K. Kopka and G. Smith and
                      A. Makarem$^*$},
      title        = {{S}ynthesis and application of a thiol-reactive {HBED}-type
                      chelator for development of easy-to-produce
                      {G}a-radiopharmaceutical kits and imaging probes.},
      journal      = {Organic $\&$ biomolecular chemistry},
      volume       = {19},
      number       = {8},
      issn         = {1477-0539},
      address      = {Cambridge},
      publisher    = {Royal Society of Chemistry},
      reportid     = {DKFZ-2021-00277},
      pages        = {1722-1726},
      year         = {2021},
      note         = {#EA:A390#LA:E030# /Division of Radiopharmaceutical
                      Chemistry,2021 Mar 4;19(8):1722-1726},
      abstract     = {In radiopharmaceutical syntheses, maleimide is commonly
                      used for linking thiol-bearing bioactive molecules to
                      metal-complexing ligands (chelators). However, due to
                      instability of the resulting linkage, phenyloxadiazolyl
                      methylsulfone (PODS) was developed as an alternative to
                      maleimide. This coupling strategy has never been attempted
                      with HBED which is a powerful chelator for
                      gallium-radiolabeling especially at ambient temperature.
                      Here we present HBED-CC-PODS as a bifunctional chelator
                      scaffold for the site-selective conjugation of thiol-bearing
                      vectors and [68Ga]Ga-radiolabeling.},
      cin          = {A390 / E030},
      ddc          = {540},
      cid          = {I:(DE-He78)A390-20160331 / I:(DE-He78)E030-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33527964},
      doi          = {10.1039/D0OB02513E},
      url          = {https://inrepo02.dkfz.de/record/167329},
}