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000167330 041__ $$aeng
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000167330 1001_ $$00000-0002-2943-6786$$aTruong, Thérèse$$b0
000167330 245__ $$aMultiethnic genome-wide association study of differentiated thyroid cancer in the EPITHYR consortium.
000167330 260__ $$aBognor Regis$$bWiley-Liss$$c2021
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000167330 500__ $$aThomsen Molecular Genetic Epidemiology 2021 Jun 15;148(12):2935-2946
000167330 520__ $$aIncidence of differentiated thyroid carcinoma (DTC) varies considerably between ethnic groups, with particularly high incidence rates in Pacific Islanders. DTC is one of the cancers with the highest familial risk suggesting a major role of genetic risk factors, but only few susceptibility loci were identified so far. In order to assess the contribution of known DTC susceptibility loci and to identify new ones, we conducted a multiethnic genome-wide association study (GWAS) in individuals of European ancestry and of Oceanian ancestry from Pacific Islands. Our study included 1,554 cases/1,973 controls of European ancestry and 301 cases/348 controls of Oceanian ancestry from seven population based case-control studies participating to the EPITHYR consortium. All participants were genotyped using the OncoArray-500K Beadchip (Illumina). We confirmed the association with the known DTC susceptibility loci at 2q35, 8p12, 9q22.33 and 14q13.3 in the European ancestry population and suggested two novel signals at 1p31.3 and 16q23.2, which were associated with thyroid stimulating hormone levels in previous GWAS. We additionally replicated an association with 5p15.33 reported previously in Chinese and European populations. Except at 1p31.3, all associations were in the same direction in the population of Oceanian ancestry. We also observed that the frequencies of risk alleles at 2q35, 5p15.33 and 16q23.2 were significantly higher in Oceanians than in Europeans. However, additional GWAS and epidemiological studies in Oceanian populations are needed to fully understand the highest incidence observed in these populations.
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000167330 650_7 $$2Other$$acase-control study
000167330 650_7 $$2Other$$agenome-wide association study
000167330 650_7 $$2Other$$athyroid cancer
000167330 7001_ $$00000-0001-7404-4549$$aLesueur, Fabienne$$b1
000167330 7001_ $$aSugier, Pierre-Emmanuel$$b2
000167330 7001_ $$aGuibon, Julie$$b3
000167330 7001_ $$aXhaard, Constance$$b4
000167330 7001_ $$aKarimi, Mojgan$$b5
000167330 7001_ $$aKulkarni, Om$$b6
000167330 7001_ $$aLucotte, Elise A$$b7
000167330 7001_ $$aBacq-Daian, Delphine$$b8
000167330 7001_ $$aBoland-Auge, Anne$$b9
000167330 7001_ $$aMulot, Claire$$b10
000167330 7001_ $$aLaurent-Puig, Pierre$$b11
000167330 7001_ $$aSchvartz, Claire$$b12
000167330 7001_ $$aGuizard, Anne-Valérie$$b13
000167330 7001_ $$aRen, Yan$$b14
000167330 7001_ $$aAdjadj, Elisabeth$$b15
000167330 7001_ $$aRachédi, Frédérique$$b16
000167330 7001_ $$aBorson-Chazot, Francoise$$b17
000167330 7001_ $$aOrtiz, Rosa Maria$$b18
000167330 7001_ $$aLence-Anta, Juan J$$b19
000167330 7001_ $$aPereda, Celia María$$b20
000167330 7001_ $$aComiskey, Daniel F$$b21
000167330 7001_ $$aHe, Huiling$$b22
000167330 7001_ $$aLiyanarachchi, Sandya$$b23
000167330 7001_ $$ade la Chapelle, Albert$$b24
000167330 7001_ $$aElisei, Rossella$$b25
000167330 7001_ $$aGemignani, Federica$$b26
000167330 7001_ $$0P:(DE-He78)9af7dea9c075a972fcfa22b583471dae$$aThomsen, Hauke$$b27
000167330 7001_ $$0P:(DE-He78)f26164c08f2f14abcf31e52e13ee3696$$aForsti, Asta$$b28$$udkfz
000167330 7001_ $$aHerzig, Anthony F$$b29
000167330 7001_ $$aLeutenegger, Anne-Louise$$b30
000167330 7001_ $$aRubino, Carole$$b31
000167330 7001_ $$aOstroumova, Evgenia$$b32
000167330 7001_ $$aKesminiene, Ausrele$$b33
000167330 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b34
000167330 7001_ $$aDeleuze, Jean-François$$b35
000167330 7001_ $$aGuénel, Pascal$$b36
000167330 7001_ $$ade Vathaire, Florent$$b37
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