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@ARTICLE{Truong:167330,
      author       = {T. Truong and F. Lesueur and P.-E. Sugier and J. Guibon and
                      C. Xhaard and M. Karimi and O. Kulkarni and E. A. Lucotte
                      and D. Bacq-Daian and A. Boland-Auge and C. Mulot and P.
                      Laurent-Puig and C. Schvartz and A.-V. Guizard and Y. Ren
                      and E. Adjadj and F. Rachédi and F. Borson-Chazot and R. M.
                      Ortiz and J. J. Lence-Anta and C. M. Pereda and D. F.
                      Comiskey and H. He and S. Liyanarachchi and A. de la
                      Chapelle and R. Elisei and F. Gemignani and H. Thomsen$^*$
                      and A. Forsti$^*$ and A. F. Herzig and A.-L. Leutenegger and
                      C. Rubino and E. Ostroumova and A. Kesminiene and M.-C.
                      Boutron-Ruault and J.-F. Deleuze and P. Guénel and F. de
                      Vathaire},
      title        = {{M}ultiethnic genome-wide association study of
                      differentiated thyroid cancer in the {EPITHYR} consortium.},
      journal      = {International journal of cancer},
      volume       = {148},
      number       = {12},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-00278},
      pages        = {2935-2946},
      year         = {2021},
      note         = {Thomsen Molecular Genetic Epidemiology 2021 Jun
                      15;148(12):2935-2946},
      abstract     = {Incidence of differentiated thyroid carcinoma (DTC) varies
                      considerably between ethnic groups, with particularly high
                      incidence rates in Pacific Islanders. DTC is one of the
                      cancers with the highest familial risk suggesting a major
                      role of genetic risk factors, but only few susceptibility
                      loci were identified so far. In order to assess the
                      contribution of known DTC susceptibility loci and to
                      identify new ones, we conducted a multiethnic genome-wide
                      association study (GWAS) in individuals of European ancestry
                      and of Oceanian ancestry from Pacific Islands. Our study
                      included 1,554 cases/1,973 controls of European ancestry and
                      301 cases/348 controls of Oceanian ancestry from seven
                      population based case-control studies participating to the
                      EPITHYR consortium. All participants were genotyped using
                      the OncoArray-500K Beadchip (Illumina). We confirmed the
                      association with the known DTC susceptibility loci at 2q35,
                      8p12, 9q22.33 and 14q13.3 in the European ancestry
                      population and suggested two novel signals at 1p31.3 and
                      16q23.2, which were associated with thyroid stimulating
                      hormone levels in previous GWAS. We additionally replicated
                      an association with 5p15.33 reported previously in Chinese
                      and European populations. Except at 1p31.3, all associations
                      were in the same direction in the population of Oceanian
                      ancestry. We also observed that the frequencies of risk
                      alleles at 2q35, 5p15.33 and 16q23.2 were significantly
                      higher in Oceanians than in Europeans. However, additional
                      GWAS and epidemiological studies in Oceanian populations are
                      needed to fully understand the highest incidence observed in
                      these populations.},
      keywords     = {case-control study (Other) / genome-wide association study
                      (Other) / thyroid cancer (Other)},
      cin          = {B062 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Funktionelle und strukturelle Genomforschung
                      (POF4-312)},
      pid          = {G:(DE-HGF)POF4-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33527407},
      doi          = {10.1002/ijc.33488},
      url          = {https://inrepo02.dkfz.de/record/167330},
}