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@ARTICLE{Niedermaier:167351,
      author       = {T. Niedermaier$^*$ and T. Gredner$^*$ and S. Kuznia$^*$ and
                      B. Schöttker$^*$ and U. Mons$^*$ and H. Brenner$^*$},
      title        = {{V}itamin {D} supplementation to the older adult population
                      in {G}ermany has the cost-saving potential of preventing
                      almost 30,000 cancer deaths per year.},
      journal      = {Molecular oncology},
      volume       = {15},
      number       = {8},
      issn         = {1878-0261},
      address      = {Hoboken, NJ},
      publisher    = {John Wiley $\&$ Sons, Inc.},
      reportid     = {DKFZ-2021-00297},
      pages        = {1986-1994},
      year         = {2021},
      note         = {#EA:C070#LA:C070#/ 2021 Aug;15(8):1986-1994},
      abstract     = {Recent meta-analyses of randomized controlled trials (RCTs)
                      have demonstrated significant reduction of cancer mortality
                      by vitamin D supplementation. We estimated costs and savings
                      for preventing cancer deaths by vitamin D supplementation of
                      the population aged 50+ years in Germany. Our analysis is
                      based on national data on cancer mortality in 2016. The
                      number of preventable cancer deaths was estimated by
                      multiplying cancer deaths above age 50 with the estimated
                      proportionate reduction of cancer mortality derived by
                      vitamin D supplementation according to meta-analyses of RCTs
                      $(13\%).$ Saved costs were estimated by multiplying this
                      number by estimated end-of-life cancer care costs
                      (€40,000). Annual costs of vitamin D supplementation were
                      estimated at 25€ per person above age 50. Comprehensive
                      sensitivity analyses were conducted. In the main analysis,
                      vitamin D supplementation was estimated to prevent almost
                      30,000 cancer deaths per year at approximate costs of €900
                      million and savings of €1.154 billion, suggesting net
                      savings of €254 million. Our results support promotion of
                      supplementation of vitamin D among older adults as a cost
                      saving approach to substantially reduce cancer mortality.},
      keywords     = {cancer mortality (Other) / cost-saving (Other) / prevention
                      (Other) / supplementation (Other) / vitamin D (Other)},
      cin          = {C070 / C120 / HD01 / M050},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)M050-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33540476},
      doi          = {10.1002/1878-0261.12924},
      url          = {https://inrepo02.dkfz.de/record/167351},
}