%0 Journal Article
%A Korshunov, Andrey
%A Okonechnikov, Konstantin
%A Schmitt-Hoffner, Felix
%A Ryzhova, Marina
%A Sahm, Felix
%A Stichel, Damian
%A Schrimpf, Daniel
%A Reuss, David E
%A Sievers, Philipp
%A Suwala, Abigail Kora
%A Kumirova, Ella
%A Zheludkova, Olga
%A Golanov, Andrey
%A Jones, David T W
%A Pfister, Stefan M
%A Kool, Marcel
%A von Deimling, Andreas
%T Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation.
%J Acta Neuropathologica Communications
%V 9
%N 1
%@ 2051-5960
%C London
%I Biomed Central
%M DKFZ-2021-00302
%P 20
%D 2021
%Z #EA:B300#LA:B300#
%X Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining molecular markers. CNS neuroblastoma with forkhead box R2 (FOXR2) activation (CNS_NBL) emerged as a distinct pediatric brain tumor entity from a pool previously diagnosed as primitive neuroectodermal tumors of the central nervous system (CNS-PNETs). Current standard of identifying CNS_NBL relies on molecular analysis. We set out to establish immunohistochemical markers allowing safely distinguishing CNS_NBL from morphological mimics. To this aim we analyzed a series of 84 brain tumors institutionally diagnosed as CNS-PNET. As expected, epigenetic analysis revealed different methylation groups corresponding to the (1) CNS-NBL (24
%K CNS-PNET (Other)
%K FOXR2-activation (Other)
%K Neuroblastoma (Other)
%K SOX10 (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33536079
%R 10.1186/s40478-021-01118-5
%U https://inrepo02.dkfz.de/record/167356