TY  - JOUR
AU  - Korshunov, Andrey
AU  - Okonechnikov, Konstantin
AU  - Schmitt-Hoffner, Felix
AU  - Ryzhova, Marina
AU  - Sahm, Felix
AU  - Stichel, Damian
AU  - Schrimpf, Daniel
AU  - Reuss, David E
AU  - Sievers, Philipp
AU  - Suwala, Abigail Kora
AU  - Kumirova, Ella
AU  - Zheludkova, Olga
AU  - Golanov, Andrey
AU  - Jones, David T W
AU  - Pfister, Stefan M
AU  - Kool, Marcel
AU  - von Deimling, Andreas
TI  - Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation.
JO  - Acta Neuropathologica Communications
VL  - 9
IS  - 1
SN  - 2051-5960
CY  - London
PB  - Biomed Central
M1  - DKFZ-2021-00302
SP  - 20
PY  - 2021
N1  - #EA:B300#LA:B300#
AB  - Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly malignant neoplasms posing diagnostic challenge due to a lack of defining molecular markers. CNS neuroblastoma with forkhead box R2 (FOXR2) activation (CNS_NBL) emerged as a distinct pediatric brain tumor entity from a pool previously diagnosed as primitive neuroectodermal tumors of the central nervous system (CNS-PNETs). Current standard of identifying CNS_NBL relies on molecular analysis. We set out to establish immunohistochemical markers allowing safely distinguishing CNS_NBL from morphological mimics. To this aim we analyzed a series of 84 brain tumors institutionally diagnosed as CNS-PNET. As expected, epigenetic analysis revealed different methylation groups corresponding to the (1) CNS-NBL (24
KW  - CNS-PNET (Other)
KW  - FOXR2-activation (Other)
KW  - Neuroblastoma (Other)
KW  - SOX10 (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33536079
DO  - DOI:10.1186/s40478-021-01118-5
UR  - https://inrepo02.dkfz.de/record/167356
ER  -