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@ARTICLE{Lin:167361,
      author       = {H.-Y. Lin and X. Wang and T.-S. Tseng and Y.-H. Kao and Z.
                      Fang and P. E. Molina and C.-H. Cheng and A. E. Berglund and
                      R. A. Eeles and K. R. Muir and N. Pashayan and C. A. Haiman
                      and H. Brenner$^*$ and T. P. Consortium and J. Y. Park},
      title        = {{A}lcohol {I}ntake and {A}lcohol-{SNP} {I}nteractions
                      {A}ssociated with {P}rostate {C}ancer {A}ggressiveness.},
      journal      = {Journal of Clinical Medicine},
      volume       = {10},
      number       = {3},
      issn         = {2077-0383},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-00307},
      pages        = {553},
      year         = {2021},
      abstract     = {Excessive alcohol intake is a well-known modifiable risk
                      factor for many cancers. It is still unclear whether genetic
                      variants or single nucleotide polymorphisms (SNPs) can
                      modify alcohol intake's impact on prostate cancer (PCa)
                      aggressiveness. The objective is to test the alcohol-SNP
                      interactions of the 7501 SNPs in the four pathways
                      (angiogenesis, mitochondria, miRNA, and androgen
                      metabolism-related pathways) associated with PCa
                      aggressiveness. We evaluated the impacts of three excessive
                      alcohol intake behaviors in 3306 PCa patients with European
                      ancestry from the PCa Consortium. We tested the alcohol-SNP
                      interactions using logistic models with the
                      discovery-validation study design. All three excessive
                      alcohol intake behaviors were not significantly associated
                      with PCa aggressiveness. However, the interactions of
                      excessive alcohol intake and three SNPs (rs13107662 [CAMK2D,
                      p = 6.2 × 10-6], rs9907521 [PRKCA,p = 7.1 × 10-5], and
                      rs11925452 [ROBO1,p = 8.2 × 10-4]) were significantly
                      associated with PCa aggressiveness. These alcohol-SNP
                      interactions revealed contrasting effects of excessive
                      alcohol intake on PCa aggressiveness according to the
                      genotypes in the identified SNPs. We identified PCa patients
                      with the rs13107662 (CAMK2D) AA genotype, the rs11925452
                      (ROBO1) AA genotype, and the rs9907521 (PRKCA) AG genotype
                      were more vulnerable to excessive alcohol intake for
                      developing aggressive PCa. Our findings support that the
                      impact of excessive alcohol intake on PCa aggressiveness was
                      varied by the selected genetic profiles.},
      keywords     = {SNP interaction (Other) / alcohol intake (Other) / prostate
                      cancer (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33540941},
      doi          = {10.3390/jcm10030553},
      url          = {https://inrepo02.dkfz.de/record/167361},
}