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@ARTICLE{Rehm:167435,
      author       = {M. Rehm and G. Büchele and R. E. Brenner and K.-P.
                      Günther and H. Brenner$^*$ and W. Koenig and D.
                      Rothenbacher},
      title        = {{R}epeated {M}easurements of {C}ardiac {T}roponin {T} and
                      {N}-{T}erminal {P}ro-{B}-{T}ype {N}atriuretic {P}eptide to
                      {A}ssess {L}ong-{T}erm {M}ortality {R}isk in {S}ubjects with
                      {O}steoarthritis.},
      journal      = {Biomolecules},
      volume       = {11},
      number       = {2},
      issn         = {2218-273X},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DKFZ-2021-00339},
      pages        = {230},
      year         = {2021},
      abstract     = {Osteoarthritis (OA) is associated with higher
                      cardiovascular mortality risk. High-sensitivity cardiac
                      troponin T (hs-cTnT) and N-terminal pro-B-type natriuretic
                      peptide (NT-proBNP) are well-characterized prognostic
                      cardiac markers. We aimed to describe the changes in
                      biomarkers measured one year apart in a cohort of 347
                      subjects with OA who underwent hip or knee replacement
                      surgery in 1995/1996 and to analyze the prognostic value of
                      repeated measurements for long-term mortality. During a
                      median follow-up of 19 years, 209 $(60.2\%)$ subjects died.
                      Substantial changes in cardiac biomarkers, especially for
                      NT-proBNP, and an independent prognostic value of NT-proBNP
                      for long-term mortality were found for both baseline
                      measurement concentration (hazard ratio (HR) 1.32, $95\%$
                      confidence interval (CI) (1.13-1.55)) and follow-up
                      measurement concentration (HR 1.39, $95\%$ CI 1.18-1.64)
                      (all HR per standard deviation increase after natural
                      log-transformation). Baseline concentrations were correlated
                      with follow-up concentrations of NT-proBNP and no longer
                      showed prognostic value when included simultaneously in a
                      single model (HR 1.08, $95\%$ CI 0.86-1.37), whereas the
                      estimate for the one-year measurement remained robust (HR
                      1.31, $95\%$ CI 1.04-1.66). Therefore, no significant
                      additional benefit of repeated NT-proBNP measurements was
                      found in this cohort, facilitating the use of a single
                      NT-proBNP measurement as a stable prognostic marker.},
      keywords     = {N-terminal pro-B-type natriuretic peptide (NT-proBNP)
                      (Other) / cohort study (Other) / high-sensitivity cardiac
                      troponin T (hs-cTnT) (Other) / mortality (Other) /
                      osteoarthritis (Other) / repeated measurements (Other)},
      cin          = {C070 / C120 / HD01},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33562838},
      doi          = {10.3390/biom11020230},
      url          = {https://inrepo02.dkfz.de/record/167435},
}