TY  - JOUR
AU  - Gies, Anton
AU  - Niedermaier, Tobias
AU  - Gruner, Laura Fiona
AU  - Heisser, Thomas
AU  - Schrotz-King, Petra
AU  - Brenner, Hermann
TI  - Fecal Immunochemical Tests Detect Screening Participants with Multiple Advanced Adenomas Better than T1 Colorectal Cancers.
JO  - Cancers
VL  - 13
IS  - 4
SN  - 2072-6694
CY  - Basel
PB  - MDPI
M1  - DKFZ-2021-00340
SP  - 644 
PY  - 2021
N1  - #EA:C120#LA:C070#
AB  - Fecal immunochemical tests (FITs) are widely used for colorectal cancer (CRC) screening. The detection of early-stage cancer and advanced adenoma (AA), the most important premalignant lesion, is highly relevant to reducing CRC-related deaths. We aimed to assess sensitivity for the detection of CRC and AA stratified by tumor stage; number; size; histology of AA; and by location, age, sex, and body mass index (BMI).Participants of screening colonoscopy (n = 2043) and newly diagnosed CRC patients (n = 184) provided a stool sample before bowel preparation or CRC surgery. Fecal hemoglobin concentration was determined in parallel by nine different quantitative FITs among 94 CRC patients, 200 AA cases, and 300 participants free of advanced neoplasm. Sensitivities were calculated at original cutoffs and at adjusted cutoffs, yielding 93
KW  - advanced neoplasia (Other)
KW  - colon cancer (Other)
KW  - early detection (Other)
KW  - fecal occult blood test (Other)
KW  - prevention (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33562775
DO  - DOI:10.3390/cancers13040644
UR  - https://inrepo02.dkfz.de/record/167436
ER  -