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@ARTICLE{Karger:167443,
      author       = {C. Karger$^*$ and C. Glowa$^*$ and P. Peschke$^*$ and W.
                      Kraft-Weyrather},
      title        = {{T}he {RBE} in ion beam radiotherapy: {I}n vivo studies and
                      clinical application.},
      journal      = {Zeitschrift für medizinische Physik},
      volume       = {31},
      number       = {2},
      issn         = {0939-3889},
      address      = {Amsterdam},
      publisher    = {Elsevier, Urban $\&$ Fischer45882},
      reportid     = {DKFZ-2021-00347},
      pages        = {105-121},
      year         = {2021},
      note         = {#EA:E040# / 31(2):105-121},
      abstract     = {Ion beams used for radiotherapy exhibit an increased
                      relative biological effectiveness (RBE), which depends on
                      several physical treatment parameters as well as on
                      biological factors of the irradiated tissues. While the RBE
                      is an experimentally well-defined quantity, translation to
                      patients is complex and requires radiobiological studies,
                      dedicated models to calculate the RBE in treatment planning
                      as well as strategies for dose prescription. Preclinical in
                      vivo studies and analysis of clinical outcome are important
                      to validate and refine RBE-models. This review describes the
                      concept of the experimental and clinical RBE and explains
                      the fundamental dependencies of the RBE based on in vitro
                      experiments. The available preclinical in vivo studies on
                      normal tissue and tumor RBE for ions heavier than protons
                      are reviewed in the context of the historical and present
                      development of ion beam radiotherapy. In addition, the role
                      of in vivo RBE-values in the development and benchmarking of
                      RBE-models as well as the transition of these models to
                      clinical application are described. Finally, limitations in
                      the translation of experimental RBE-values into clinical
                      application and the direction of future research are
                      discussed.},
      subtyp        = {Review Article},
      keywords     = {Clinical application (Other) / Ion beam radiotherapy
                      (Other) / Preclinical in vitro and in vivo studies (Other) /
                      RBE validation (Other) / Relative biological effectiveness
                      (RBE) (Other)},
      cin          = {E040},
      ddc          = {610},
      cid          = {I:(DE-He78)E040-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33568337},
      doi          = {10.1016/j.zemedi.2020.12.001},
      url          = {https://inrepo02.dkfz.de/record/167443},
}