%0 Journal Article
%A Baroni, Lorena
%A Sundaresan, Lakshmikirupa
%A Heled, Ayala
%A Coltin, Hallie
%A Pajtler, Kristian W
%A Lin, Tong
%A Merchant, Thomas E
%A McLendon, Roger
%A Faria, Claudia
%A Buntine, Molly
%A White, Christine L
%A Pfister, Stefan M
%A Gilbert, Mark R
%A Armstrong, Terri S
%A Bouffet, Eric
%A Kumar, Sachin
%A Taylor, Michael D
%A Aldape, Kenneth D
%A Ellison, David W
%A Gottardo, Nicholas G
%A Kool, Marcel
%A Korshunov, Andrey
%A Hansford, Jordan R
%A Ramaswamy, Vijay
%T Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q.
%J Neuro-Oncology
%V 23
%N 8
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2021-00359
%P 1360-1370
%D 2021
%Z 2021 Aug 2;23(8):1360-1370
%X Within PF-EPN-A, 1q gain is a marker of poor prognosis, however, it is unclear if within PF-EPN-A additional cytogenetic events exist which can refine risk stratification.Five independent non-overlapping cohorts of PF-EPN-A were analyzed applying genome wide methylation arrays for chromosomal and clinical variables predictive of survival.Across all cohorts, 663 PF-EPN-A were identified. The most common broad copy number event was 1q gain (18.9
%K 1q gain (Other)
%K 6qloss (Other)
%K PFA (Other)
%K PFB (Other)
%K ependymoma (Other)
%K posterior fossa (Other)
%K subgrouping (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33580238
%R 10.1093/neuonc/noab034
%U https://inrepo02.dkfz.de/record/167455