TY  - JOUR
AU  - Baroni, Lorena
AU  - Sundaresan, Lakshmikirupa
AU  - Heled, Ayala
AU  - Coltin, Hallie
AU  - Pajtler, Kristian W
AU  - Lin, Tong
AU  - Merchant, Thomas E
AU  - McLendon, Roger
AU  - Faria, Claudia
AU  - Buntine, Molly
AU  - White, Christine L
AU  - Pfister, Stefan M
AU  - Gilbert, Mark R
AU  - Armstrong, Terri S
AU  - Bouffet, Eric
AU  - Kumar, Sachin
AU  - Taylor, Michael D
AU  - Aldape, Kenneth D
AU  - Ellison, David W
AU  - Gottardo, Nicholas G
AU  - Kool, Marcel
AU  - Korshunov, Andrey
AU  - Hansford, Jordan R
AU  - Ramaswamy, Vijay
TI  - Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q.
JO  - Neuro-Oncology
VL  - 23
IS  - 8
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2021-00359
SP  - 1360-1370
PY  - 2021
N1  - 2021 Aug 2;23(8):1360-1370
AB  - Within PF-EPN-A, 1q gain is a marker of poor prognosis, however, it is unclear if within PF-EPN-A additional cytogenetic events exist which can refine risk stratification.Five independent non-overlapping cohorts of PF-EPN-A were analyzed applying genome wide methylation arrays for chromosomal and clinical variables predictive of survival.Across all cohorts, 663 PF-EPN-A were identified. The most common broad copy number event was 1q gain (18.9
KW  - 1q gain (Other)
KW  - 6qloss (Other)
KW  - PFA (Other)
KW  - PFB (Other)
KW  - ependymoma (Other)
KW  - posterior fossa (Other)
KW  - subgrouping (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33580238
DO  - DOI:10.1093/neuonc/noab034
UR  - https://inrepo02.dkfz.de/record/167455
ER  -