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@ARTICLE{Goerke:167469,
      author       = {S. Goerke$^*$ and J. Breitling$^*$ and A. Korzowski$^*$ and
                      D. Paech$^*$ and M. Zaiss and H.-P. Schlemmer$^*$ and M. E.
                      Ladd$^*$ and P. Bachert$^*$},
      title        = {{C}linical routine acquisition protocol for 3{D}
                      relaxation-compensated {APT} and r{NOE} {CEST}-{MRI} of the
                      human brain at 3{T}.},
      journal      = {Magnetic resonance in medicine},
      volume       = {86},
      number       = {1},
      issn         = {0740-3194},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-00372},
      pages        = {393-404},
      year         = {2021},
      note         = {#EA:E020#LA:E020# / 86(1):393-404},
      abstract     = {The value of relaxation-compensated amide proton transfer
                      (APT) and relayed nuclear Overhauser effect (rNOE) chemical
                      exchange saturation transfer (CEST)-MRI has already been
                      demonstrated in various neuro-oncological clinical
                      applications. Recently, we translated the approach from 7T
                      to a clinically relevant magnetic field strength of 3T.
                      However, the overall acquisition time was still too long for
                      a broad application in the clinical setting. The aim of this
                      study was to establish a shorter acquisition protocol whilst
                      maintaining the contrast behavior and reproducibility.Ten
                      patients with glioblastoma were examined using the previous
                      state-of-the-art acquisition protocol at 3T. The acquired
                      spectral data were retrospectively reduced to find the
                      minimal amount of required information that allows obtaining
                      the same contrast behavior. To further reduce the
                      acquisition time, also the image readout was accelerated and
                      the pre-saturation parameters were further optimized.In
                      total, the overall acquisition time could be reduced from 19
                      min to under 7 min. One key finding was that, when evaluated
                      by the relaxation-compensated inverse metric, a contrast
                      correction for B1 -field inhomogeneities at 3T can also be
                      achieved reliably with CEST data at only one B1 value. In
                      contrast, a 1-point B1 -correction was not sufficient for
                      the common linear difference evaluation. The reproducibility
                      of the new clinical routine acquisition protocol was similar
                      to the previous state-of-the-art protocol with limits of
                      agreement below $20\%.The$ substantial reduction in
                      acquisition time by about $64\%$ now allows the application
                      of 3D relaxation-compensated APT and rNOE CEST-MRI for
                      examinations of the human brain at 3T in clinical routine.},
      keywords     = {APT (Other) / CEST (Other) / MRI (Other) / cancer (Other) /
                      proteins (Other) / rNOE (Other)},
      cin          = {E020 / E010},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331 / I:(DE-He78)E010-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33586217},
      doi          = {10.1002/mrm.28699.},
      url          = {https://inrepo02.dkfz.de/record/167469},
}