%0 Journal Article
%A Fisher, Michael J
%A Jones, David T W
%A Li, Yimei
%A Guo, Xiaofan
%A Sonawane, Poonam S
%A Waanders, Angela J
%A Phillips, Joanna J
%A Weiss, William A
%A Resnick, Adam C
%A Gosline, Sara
%A Banerjee, Jineta
%A Guinney, Justin
%A Gnekow, Astrid
%A Kandels, Daniela
%A Foreman, Nicholas K
%A Korshunov, Andrey
%A Ryzhova, Marina
%A Massimi, Luca
%A Gururangan, Sri
%A Kieran, Mark W
%A Wang, Zhihong
%A Fouladi, Maryam
%A Sato, Mariko
%A Øra, Ingrid
%A Holm, Stefan
%A Markham, Stephen J
%A Beck, Pengbo
%A Jäger, Natalie
%A Wittmann, Andrea
%A Sommerkamp, Alexander C
%A Sahm, Felix
%A Pfister, Stefan
%A Gutmann, David H
%T Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1).
%J Acta neuropathologica
%V 141
%N 4
%@ 0001-6322
%C Heidelberg
%I Springer
%M DKFZ-2021-00373
%P 605-617
%D 2021
%Z 2021 Apr;141(4):605-617 / #EA:B360#LA:B062#
%X Low-grade gliomas (LGGs) are the most common childhood brain tumor in the general population and in individuals with the Neurofibromatosis type 1 (NF1) cancer predisposition syndrome. Surgical biopsy is rarely performed prior to treatment in the setting of NF1, resulting in a paucity of tumor genomic information. To define the molecular landscape of NF1-associated LGGs (NF1-LGG), we integrated clinical data, histological diagnoses, and multi-level genetic/genomic analyses on 70 individuals from 25 centers worldwide. Whereas, most tumors harbored bi-allelic NF1 inactivation as the only genetic abnormality, 11
%K FGFR1 (Other)
%K Methylation (Other)
%K Neurofibromatosis (Other)
%K Pediatric brain tumor (Other)
%K Pilocytic astrocytoma (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33585982
%R 10.1007/s00401-021-02276-5.
%U https://inrepo02.dkfz.de/record/167470