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000167485 1001_ $$aBehjati, Sam$$b0
000167485 245__ $$aMaturation Block in Childhood Cancer.
000167485 260__ $$aPhiladelphia, Pa.$$c2021
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000167485 500__ $$a#LA:B062#2021 Mar;11(3):542-544
000167485 520__ $$aThe key differences between tumors arising in children and those in adults stem from the cellular origin of cancer at different ages, with adult cancers arising within aging cell hierarchies, as a consequence of accumulated damage and mutagenesis, in contrast to childhood tumors that are born in aberrantly developing tissues. A distinct biological property of childhood tumor cells-a block of developmental maturation-may hold the key to advancing the treatment of childhood cancer beyond cytotoxic strategies.
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000167485 7001_ $$00000-0001-7539-9472$$aGilbertson, Richard J$$b1
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