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| 024 | 7 | _ | |a 10.1038/s41467-021-21297-y |2 doi |
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| 037 | _ | _ | |a DKFZ-2021-00397 |
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| 100 | 1 | _ | |a Xydia, Maria |0 P:(DE-He78)d3f0a48c15b355dfeae29fd5137d8bcb |b 0 |e First author |
| 245 | _ | _ | |a Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients. |
| 260 | _ | _ | |a [London] |c 2021 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a Regulatory CD4+ T cells (Treg) prevent tumor clearance by conventional T cells (Tconv) comprising a major obstacle of cancer immune-surveillance. Hitherto, the mechanisms of Treg repertoire formation in human cancers remain largely unclear. Here, we analyze Treg clonal origin in breast cancer patients using T-Cell Receptor and single-cell transcriptome sequencing. While Treg in peripheral blood and breast tumors are clonally distinct, Tconv clones, including tumor-antigen reactive effectors (Teff), are detected in both compartments. Tumor-infiltrating CD4+ cells accumulate into distinct transcriptome clusters, including early activated Tconv, uncommitted Teff, Th1 Teff, suppressive Treg and pro-tumorigenic Treg. Trajectory analysis suggests early activated Tconv differentiation either into Th1 Teff or into suppressive and pro-tumorigenic Treg. Importantly, Tconv, activated Tconv and Treg share highly-expanded clones contributing up to 65% of intratumoral Treg. Here we show that Treg in human breast cancer may considerably stem from antigen-experienced Tconv converting into secondary induced Treg through intratumoral activation. |
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| 700 | 1 | _ | |a Macaulay, Iain |b 3 |
| 700 | 1 | _ | |a Tarabichi, Maxime |b 4 |
| 700 | 1 | _ | |a Lohmayer, Robert |b 5 |
| 700 | 1 | _ | |a Wilkening, Stefan |0 P:(DE-He78)928f784868a4b5ff301367ecda92f152 |b 6 |
| 700 | 1 | _ | |a Michels, Tillmann |b 7 |
| 700 | 1 | _ | |a Brown, Daniel |b 8 |
| 700 | 1 | _ | |a Vanuytven, Sebastiaan |b 9 |
| 700 | 1 | _ | |a Mastitskaya, Svetlana |0 0000-0002-4819-2908 |b 10 |
| 700 | 1 | _ | |a Laidlaw, Sean |0 0000-0001-7658-1428 |b 11 |
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| 700 | 1 | _ | |a Müller-Steinhardt, Michael |b 17 |
| 700 | 1 | _ | |a Halama, Niels |b 18 |
| 700 | 1 | _ | |a Domschke, Christoph |b 19 |
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| 700 | 1 | _ | |a von Kalle, Christof |0 P:(DE-He78)5bacb661d5d7c0220d8f996d980ad8de |b 21 |u dkfz |
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| 700 | 1 | _ | |a Voet, Thierry |b 23 |
| 700 | 1 | _ | |a Beckhove, Philipp |0 P:(DE-He78)1732377f6242a18280bc6aaa196988d1 |b 24 |e Last author |
| 773 | _ | _ | |a 10.1038/s41467-021-21297-y |g Vol. 12, no. 1, p. 1119 |0 PERI:(DE-600)2553671-0 |n 1 |p 1119 |t Nature Communications |v 12 |y 2021 |x 2041-1723 |
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