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000167589 1001_ $$00000-0002-9386-382X$$aLinseisen, Jakob$$b0
000167589 245__ $$aRed blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
000167589 260__ $$aPhiladelphia, Pa.$$bAACR$$c2021
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000167589 520__ $$aA growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.To investigate the association between red blood cell (RBC) membrane FAs and risk of CRC in a case-control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1069 incident CRC cases were identified and matched to 1069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of CRC was estimated by multivariable adjusted conditional logistic regression models.After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for CRC (OR=1.23; 95% CI=1.07-1.42, per 1 mol%). Conversely, CRC incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62-0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.The positive association between pre-diagnostic RBC stearic acid and CRC reflects putative differences in FA intake and metabolism between cancer cases and matched controls which deserve further investigation. The inverse relationship between EPA and CRC is in line with the repeatedly reported protective effect of fish consumption on CRC risk.These findings add to the evidence on CRC prevention.
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000167589 7001_ $$aGrundmann, Nina$$b1
000167589 7001_ $$0P:(DE-He78)c5fe8e127aa143f4215a42b1e9209a80$$aZoller, Dorothee$$b2$$udkfz
000167589 7001_ $$0P:(DE-HGF)0$$aKuehn, Tilman$$b3
000167589 7001_ $$00000-0002-3151-5897$$aJansen, Eugene H J M$$b4
000167589 7001_ $$aChajes, Veronique$$b5
000167589 7001_ $$00000-0002-7805-9913$$aFedirko, Veronika$$b6
000167589 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b7
000167589 7001_ $$00000-0003-0481-2893$$aDahm, Christina C$$b8
000167589 7001_ $$aOvervad, Kim$$b9
000167589 7001_ $$00000-0003-4385-2097$$aTjonneland, Anne$$b10
000167589 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, Marie-Christine$$b11
000167589 7001_ $$00000-0002-6927-3360$$aRothwell, Joseph A$$b12
000167589 7001_ $$00000-0001-7157-419X$$aSeveri, Gianluca$$b13
000167589 7001_ $$aKaaks, Rudolf$$b14
000167589 7001_ $$00000-0002-0830-5277$$aSchulze, Matthias B$$b15
000167589 7001_ $$aAleksandrova, Krasimira$$b16
000167589 7001_ $$aSieri, Sabina$$b17
000167589 7001_ $$aPanico, Salvatore$$b18
000167589 7001_ $$00000-0003-2666-414X$$aTumino, Rosario$$b19
000167589 7001_ $$00000-0002-5758-9069$$aMasala, Giovanna$$b20
000167589 7001_ $$aDe Marco, Laura$$b21
000167589 7001_ $$aBueno-de-Mesquita, Bas$$b22
000167589 7001_ $$00000-0003-4082-8163$$aVermeulen, Roel$$b23
000167589 7001_ $$00000-0002-0031-4152$$aGram, Inger T$$b24
000167589 7001_ $$00000-0003-2476-4251$$aSkeie, Guri$$b25
000167589 7001_ $$aChirlaque, Maria-Dolores$$b26
000167589 7001_ $$00000-0001-8434-2013$$aArdanaz, Eva$$b27
000167589 7001_ $$aAgudo, Antonio$$b28
000167589 7001_ $$00000-0003-4817-0757$$aSánchez, Maria-Jose$$b29
000167589 7001_ $$aAmiano, Pilar$$b30
000167589 7001_ $$00000-0002-1673-8494$$aWennberg, Maria$$b31
000167589 7001_ $$00000-0002-8958-975X$$aBodén, Stina$$b32
000167589 7001_ $$00000-0002-5652-356X$$aPerez-Cornago, Aurora$$b33
000167589 7001_ $$00000-0002-0442-3284$$aAglago, Elom Kouassivi$$b34
000167589 7001_ $$aGunter, Marc J$$b35
000167589 7001_ $$aJenab, Mazda$$b36
000167589 7001_ $$00000-0001-6517-1300$$aHeath, Alicia K$$b37
000167589 7001_ $$aNieters, Alexandra$$b38
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