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@ARTICLE{Linseisen:167589,
      author       = {J. Linseisen and N. Grundmann and D. Zoller$^*$ and T.
                      Kuehn$^*$ and E. H. J. M. Jansen and V. Chajes and V.
                      Fedirko and E. Weiderpass and C. C. Dahm and K. Overvad and
                      A. Tjonneland and M.-C. Boutron-Ruault and J. A. Rothwell
                      and G. Severi and R. Kaaks and M. B. Schulze and K.
                      Aleksandrova and S. Sieri and S. Panico and R. Tumino and G.
                      Masala and L. De Marco and B. Bueno-de-Mesquita and R.
                      Vermeulen and I. T. Gram and G. Skeie and M.-D. Chirlaque
                      and E. Ardanaz and A. Agudo and M.-J. Sánchez and P. Amiano
                      and M. Wennberg and S. Bodén and A. Perez-Cornago and E. K.
                      Aglago and M. J. Gunter and M. Jenab and A. K. Heath and A.
                      Nieters},
      title        = {{R}ed blood cell fatty acids and risk of colorectal cancer
                      in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition ({EPIC}).},
      journal      = {Cancer epidemiology, biomarkers $\&$ prevention},
      volume       = {30},
      number       = {5},
      issn         = {1538-7755},
      address      = {Philadelphia, Pa.},
      publisher    = {AACR},
      reportid     = {DKFZ-2021-00449},
      pages        = {874-885},
      year         = {2021},
      note         = {30(5):874-885},
      abstract     = {A growing body of evidence suggests that alterations of
                      dietary fatty acid (FA) profiles are associated with
                      colorectal cancer (CRC) risk. However, data from large-scale
                      epidemiological studies using circulating FA measurements to
                      objectively assess individual FA and FA categories are
                      scarce.To investigate the association between red blood cell
                      (RBC) membrane FAs and risk of CRC in a case-control study
                      nested within a large prospective cohort. After a median
                      follow-up of 6.4 years, 1069 incident CRC cases were
                      identified and matched to 1069 controls among participants
                      of the European Prospective Investigation into Cancer and
                      Nutrition (EPIC). The FA composition of RBC phospholipids
                      (in $mol\%)$ was analyzed by gas chromatography, and their
                      association with risk of CRC was estimated by multivariable
                      adjusted conditional logistic regression models.After
                      correction for multiple testing, subjects with higher
                      concentrations of RBC stearic acid were at higher risk for
                      CRC (OR=1.23; $95\%$ CI=1.07-1.42, per 1 $mol\%).$
                      Conversely, CRC incidence decreased with increasing
                      proportions of RBC n-3 PUFA, particularly eicosapentaenoic
                      acid (0.75; 0.62-0.92, per 1 $mol\%).$ The findings for the
                      n-6 PUFA arachidonic acid were inconsistent.The positive
                      association between pre-diagnostic RBC stearic acid and CRC
                      reflects putative differences in FA intake and metabolism
                      between cancer cases and matched controls which deserve
                      further investigation. The inverse relationship between EPA
                      and CRC is in line with the repeatedly reported protective
                      effect of fish consumption on CRC risk.These findings add to
                      the evidence on CRC prevention.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33619024},
      doi          = {10.1158/1055-9965.EPI-20-1426},
      url          = {https://inrepo02.dkfz.de/record/167589},
}