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| 001 | 167590 | ||
| 005 | 20240229133544.0 | ||
| 024 | 7 | _ | |a 10.1158/1055-9965.EPI-20-1599 |2 doi |
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| 037 | _ | _ | |a DKFZ-2021-00450 |
| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Zheng, Guoqiao |0 P:(DE-He78)98a8f1a22ffc460364a8a34499118103 |b 0 |e First author |u dkfz |
| 245 | _ | _ | |a Beta-blockers use and risk of breast cancer in women with hypertension. |
| 260 | _ | _ | |a Philadelphia, Pa. |c 2021 |b AACR |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1625048925_3341 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 500 | _ | _ | |a #EA:C020# / 30(5):965-973 |
| 520 | _ | _ | |a The risk of breast cancer among hypertensive patients who use beta-blockers has attracted attention. However, the evidence is inconsistent and investigation of the dose-specific associations for subtypes of beta-blockers are limited.By incorporating Swedish national registers, breast cancer risk was estimated in women with hypertension who used nonselective beta-blockers and beta-1 selective blockers compared with propensity score-matched non-users. The cumulative defined daily dose was used to study the dose-response association. Test of interaction between beta-blocker use and other antihypertensive medications was performed.Hypertensive patients taking beta-1 selective blockers (metoprolol, atenolol, bisoprolol) had an increased risk of breast cancer with a hazard ratio (HR) and 95% confidence interval (CI) of 2.39 (1.95-2.94), 2.31 (1.46-3.64), and 3.02 (2.09-4.36), respectively. All of the observed associations were dose-dependent (P trend <0.0001). No significant association was found for the nonselective beta-blocker (propranolol) except that among users of agents acting on the renin-angiotensin system, those who used propranolol had increased breast cancer risk. Modification of agents acting on the renin-angiotensin system on breast cancer risk was also observed for atenolol.The increased risk of breast cancer associates with the use of beta-1 selective blockers in a dose-response manner.Breast cancer surveillance is recommended for hypertensive female patients using beta-1 selective blockers. |
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| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 700 | 1 | _ | |a Sundquist, Jan |b 1 |
| 700 | 1 | _ | |a Sundquist, Kristina |b 2 |
| 700 | 1 | _ | |a Ji, Jianguang |b 3 |
| 773 | _ | _ | |a 10.1158/1055-9965.EPI-20-1599 |g p. cebp.1599.2020 - |0 PERI:(DE-600)2036781-8 |n 5 |p 965-973 |t Cancer epidemiology, biomarkers & prevention |v 30 |y 2021 |x 1538-7755 |
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