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@ARTICLE{Canney:167605,
      author       = {M. Canney and S. J. Barbour and Y. Zheng and R. Coppo and
                      H. Zhang and Z.-H. Liu and K. Matsuzaki and Y. Suzuki and R.
                      Katafuchi and H. N. Reich and D. Cattran and M. L. Russo and
                      S. Troyanov and H. T. Cook and I. Roberts and V. Tesar and
                      D. Maixnerova and S. Lundberg and F. Emma and L. Fuiano and
                      G. Beltrame and C. Rollino and A. Amore and R. Camilla and
                      L. Peruzzi and M. Praga and S. Feriozzi and R. Polci and G.
                      Segoloni and L. Colla and A. Pani and D. Piras and A. Angioi
                      and G. Cancarini and S. Ravera and M. Durlik and E. Moggia
                      and J. Ballarin and S. Di Giulio and F. Pugliese and I.
                      Serriello and Y. Caliskan and M. Sever and I. Kilicaslan and
                      F. Locatelli and L. Del Vecchio and J. F. M. Wetzels and H.
                      Peters and U. Berg and F. Carvalho and A. C. da Costa
                      Ferreira and M. Maggio and A. Wiecek and M. Ots-Rosenberg
                      and R. Magistroni and R. Topaloglu and Y. Bilginer and M.
                      D'Amico and M. Stangou and F. Giacchino and D. Goumenos and
                      P. Kalliakmani and M. Gerolymos and K. Galesic and C. Geddes
                      and K. Siamopoulos and O. Balafa and M. Galliani and P.
                      Stratta and M. Quaglia and R. Bergia and R. Cravero and M.
                      Salvadori and L. Cirami and B. Fellstrom and H. K. Smerud
                      and F. Ferrario and T. Stellato and J. Egido and C. Martin
                      and J. Floege and F. Eitner and A. Lupo and P. Bernich and
                      P. Menè and M. Morosetti and C. van Kooten and T. Rabelink
                      and M. E. J. Reinders and J. M. B. Grinyo and S. Cusinato
                      and L. Benozzi and S. Savoldi and C. Licata and M.
                      Mizerska-Wasiak and G. Martina and A. Messuerotti and A. Dal
                      Canton and C. Esposito and C. Migotto and G. Triolo and F.
                      Mariano and C. Pozzi and R. Boero and S. Bellur and G.
                      Mazzucco and C. Giannakakis and E. Honsova and B. Sundelin
                      and A. M. Di Palma and F. Ferrario and E. Gutiérrez and A.
                      M. Asunis and J. Barratt and R. Tardanico and A.
                      Perkowska-Ptasinska and J. A. Terroba and M. Fortunato and
                      A. Pantzaki and Y. Ozluk and E. Steenbergen and M. Soderberg
                      and Z. Riispere and L. Furci and D. Orhan and D. Kipgen and
                      D. Casartelli and D. G. Ljubanovic and H. Gakiopoulou and E.
                      Bertoni and P. C. Ortiz and H. Karkoszka and H. J. Groene
                      and A. Stoppacciaro and I. Bajema and J. Bruijn and X. F.
                      Oliveras and J. Maldyk and E. Ioachim and N. Bavbek and T.
                      Cook and S. Troyanov and C. Alpers and A. Amore and J.
                      Barratt and J. Feehally and F. Berthoux and S. Bonsib and J.
                      Bruijn and V. D'Agati and G. D'Amico and S. Emancipator and
                      F. Emmal and F. Ferrario and F. Fervenza and S. Florquin and
                      A. Fogo and C. Geddes and H. Groene$^*$ and M. Haas and P.
                      Hill and R. Hogg and S. Hsu and T. Hunley and M. Hladunewich
                      and C. Jennette and K. Joh and B. Julian and T. Kawamura and
                      F. Lai and C. Leung and L. Li and P. Li and Z. Liu and A.
                      Massat and B. Mackinnon and S. Mezzano and F. Schena and Y.
                      Tomino and P. Walker and H. Wang and J. Weening and N.
                      Yoshikawa and C.-H. Zeng and S. Shi and H. Suzuki and K.
                      Koike and K. Hirano and T. Kawamura and T. Yokoo and M.
                      Hanai and K. Fukami and K. Takahashi and Y. Yuzawa and M.
                      Niwa and Y. Yasuda and S. Maruyama and D. Ichikawa and T.
                      Suzuki and S. Shirai and A. Fukuda and S. Fujimoto and H.
                      Trimarchi},
      collaboration = {I. I. N. Network and I. I. N. N. Investigators},
      title        = {{Q}uantifying {D}uration of {P}roteinuria {R}emission and
                      {A}ssociation with {C}linical {O}utcome in {I}g{A}
                      {N}ephropathy.},
      journal      = {Journal of the American Society of Nephrology},
      volume       = {32},
      number       = {2},
      issn         = {1533-3450},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2021-00452},
      pages        = {436 - 447},
      year         = {2021},
      note         = {Groene H (MD, Department of Cellular and Molecular
                      Pathology, German Cancer Research Center, Heidelberg,
                      Germany)},
      abstract     = {On the basis of findings of observational studies and a
                      meta-analysis, proteinuria reduction has been proposed as a
                      surrogate outcome in IgA nephropathy. How long a reduction
                      in proteinuria needs to be maintained to mitigate the
                      long-term risk of disease progression is unknown.In this
                      retrospective multiethnic cohort of adult patients with IgA
                      nephropathy, we defined proteinuria remission as a $≥25\%$
                      reduction in proteinuria from the peak value after biopsy,
                      and an absolute reduction in proteinuria to <1 g/d. The
                      exposure of interest was the total duration of first
                      remission, treated as a time-varying covariate using
                      longitudinal proteinuria measurements. We used
                      time-dependent Cox proportional hazards regression models to
                      quantify the association between the duration of remission
                      and the primary outcome (ESKD or a $50\%$ reduction in
                      eGFR).During a median follow-up of 3.9 years, 274 of 1864
                      patients $(14.7\%)$ experienced the primary outcome. The
                      relationship between duration of proteinuria remission and
                      outcome was nonlinear. Each 3 months in sustained remission
                      up to approximately 4 years was associated with an
                      additional $9\%$ reduction in the risk of disease
                      progression (hazard ratio [HR], 0.91; $95\%$ confidence
                      interval $[95\%$ CI], 0.89 to 0.93). Thereafter, each
                      additional 3 months in remission was associated with a
                      smaller, nonsignificant risk reduction (HR, 0.99; $95\%$ CI,
                      0.96 to 1.03). These findings were robust to multivariable
                      adjustment and consistent across clinical and histologic
                      subgroups.Our findings support the use of proteinuria as a
                      surrogate outcome in IgA nephropathy, but additionally
                      demonstrate the value of quantifying the duration of
                      proteinuria remission when estimating the risk of hard
                      clinical endpoints.},
      keywords     = {IgA nephropathy (Other) / end stage kidney disease (Other)
                      / epidemiology and outcomes (Other) / glomerular disease
                      (Other) / proteinuria (Other) / renal function decline
                      (Other) / renal pathology (Other)},
      cin          = {G130},
      ddc          = {610},
      cid          = {I:(DE-He78)G130-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33514642},
      doi          = {10.1681/ASN.2020030349},
      url          = {https://inrepo02.dkfz.de/record/167605},
}