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@ARTICLE{Liebert:167634,
      author       = {A. Liebert and K. Tkotz and J. Herrler and P. Linz and A.
                      Mennecke and A. German and P. Liebig and R. Gumbrecht and M.
                      Schmidt and A. Doerfler and M. Uder and M. Zaiss and A.
                      Nagel$^*$},
      title        = {{W}hole-brain quantitative {CEST} {MRI} at 7{T} using
                      parallel transmission methods and {B} 1 + correction.},
      journal      = {Magnetic resonance in medicine},
      volume       = {86},
      number       = {1},
      issn         = {1522-2594},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2021-00468},
      pages        = {346-362},
      year         = {2021},
      note         = {#LA:E020# / 86(1):346-362},
      abstract     = {To enable whole-brain quantitative CEST MRI at ultra-high
                      magnetic field strengths (B0 ≥ 7T) within short
                      acquisition times.Multiple interleaved mode saturation
                      (MIMOSA) was combined with fast online-customized (FOCUS)
                      parallel transmission (pTx) excitation pulses and B 1 +
                      correction to achieve homogenous whole-brain coverage.
                      Examinations of 13 volunteers were performed on a 7T MRI
                      system with 3 different types of pulse sequences: (1)
                      saturation in circular polarized (CP) mode and CP mode
                      readout, (2) MIMOSA and CP readout, and (3) MIMOSA and FOCUS
                      readout. For comparison, the inverse magnetic transfer ratio
                      metric for relayed nuclear Overhauser effect and amide
                      proton transfer were calculated. To investigate the number
                      of required acquisitions for a good B 1 + correction, 4
                      volunteers were measured with 6 different B1 amplitudes.
                      Finally, time point repeatability was investigated for 6
                      volunteers.MIMOSA FOCUS sequence using B 1 + correction,
                      with both single and multiple points, reduced inhomogeneity
                      of the CEST contrasts around the occipital lobe and
                      cerebellum. Results indicate that the most stable
                      inter-subject coefficient of variation was achieved using
                      the MIMOSA FOCUS sequence. Time point repeatability of
                      MIMOSA FOCUS with single-point B 1 + correction showed a
                      maximum coefficient of variation below $8\%$ for 3
                      measurements in a single volunteer.A combination of MIMOSA
                      FOCUS with a single-point B 1 + correction can be used to
                      achieve quantitative CEST measurements at ultra-high
                      magnetic field strengths. Compared to previous B 1 +
                      correction methods, acquisition time can be reduced as
                      additional scans required for B 1 + correction can be
                      omitted.},
      keywords     = {7T (Other) / chemical exchange saturation transfer (Other)
                      / fast-online customized pulses (Other) / multiple
                      interleaved mode saturation (Other) / parallel transmission
                      (Other) / spiral non-selective trajectory (Other)},
      cin          = {E020},
      ddc          = {610},
      cid          = {I:(DE-He78)E020-20160331},
      pnm          = {315 - Bildgebung und Radioonkologie (POF4-315)},
      pid          = {G:(DE-HGF)POF4-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33634505},
      doi          = {10.1002/mrm.28745},
      url          = {https://inrepo02.dkfz.de/record/167634},
}