000167638 001__ 167638
000167638 005__ 20240229133545.0
000167638 0247_ $$2doi$$a10.1136/gutjnl-2020-321534
000167638 0247_ $$2pmid$$apmid:33632709
000167638 0247_ $$2ISSN$$a0017-5749
000167638 0247_ $$2ISSN$$a1468-3288
000167638 0247_ $$2altmetric$$aaltmetric:100883991
000167638 037__ $$aDKFZ-2021-00472
000167638 041__ $$aEnglish
000167638 082__ $$a610
000167638 1001_ $$00000-0001-6027-9806$$aHuyghe, Jeroen R$$b0
000167638 245__ $$aGenetic architectures of proximal and distal colorectal cancer are partly distinct.
000167638 260__ $$aLondon$$bBMJ Publishing Group$$c2021
000167638 3367_ $$2DRIVER$$aarticle
000167638 3367_ $$2DataCite$$aOutput Types/Journal article
000167638 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1625049726_1990
000167638 3367_ $$2BibTeX$$aARTICLE
000167638 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000167638 3367_ $$00$$2EndNote$$aJournal Article
000167638 500__ $$a70(7):1325-1334
000167638 520__ $$aAn understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined.To identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling.We identified 13 loci that reached genome-wide significance (p<5×10-8) and that were not reported by previous GWASs for overall CRC risk. Multiple lines of evidence support candidate genes at several of these loci. We detected substantial heterogeneity between anatomical subsites. Just over half (61) of 109 known and new risk variants showed no evidence for heterogeneity. In contrast, 22 variants showed association with distal CRC (including rectal cancer), but no evidence for association or an attenuated association with proximal CRC. For two loci, there was strong evidence for effects confined to proximal colon cancer.Genetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.
000167638 536__ $$0G:(DE-HGF)POF4-313$$a313 - Krebsrisikofaktoren und Prävention (POF4-313)$$cPOF4-313$$fPOF IV$$x0
000167638 588__ $$aDataset connected to CrossRef, PubMed,
000167638 650_7 $$2Other$$acancer genetics
000167638 650_7 $$2Other$$acancer susceptibility
000167638 650_7 $$2Other$$acolon carcinogenesis
000167638 650_7 $$2Other$$acolorectal cancer
000167638 650_7 $$2Other$$agenetic polymorphisms
000167638 7001_ $$aHarrison, Tabitha A$$b1
000167638 7001_ $$aBien, Stephanie A$$b2
000167638 7001_ $$aHampel, Heather$$b3
000167638 7001_ $$aFigueiredo, Jane C$$b4
000167638 7001_ $$aSchmit, Stephanie L$$b5
000167638 7001_ $$aConti, David V$$b6
000167638 7001_ $$aChen, Sai$$b7
000167638 7001_ $$aQu, Conghui$$b8
000167638 7001_ $$aLin, Yi$$b9
000167638 7001_ $$aBarfield, Richard$$b10
000167638 7001_ $$aBaron, John A$$b11
000167638 7001_ $$aCross, Amanda J$$b12
000167638 7001_ $$aDiergaarde, Brenda$$b13
000167638 7001_ $$aDuggan, David$$b14
000167638 7001_ $$aHarlid, Sophia$$b15
000167638 7001_ $$aImaz, Liher$$b16
000167638 7001_ $$aKang, Hyun Min$$b17
000167638 7001_ $$aLevine, David M$$b18
000167638 7001_ $$aPerduca, Vittorio$$b19
000167638 7001_ $$aPerez-Cornago, Aurora$$b20
000167638 7001_ $$aSakoda, Lori C$$b21
000167638 7001_ $$aSchumacher, Fredrick R$$b22
000167638 7001_ $$aSlattery, Martha L$$b23
000167638 7001_ $$aToland, Amanda E$$b24
000167638 7001_ $$avan Duijnhoven, Fränzel J B$$b25
000167638 7001_ $$aVan Guelpen, Bethany$$b26
000167638 7001_ $$aAgudo, Antonio$$b27
000167638 7001_ $$aAlbanes, Demetrius$$b28
000167638 7001_ $$aAlonso, M Henar$$b29
000167638 7001_ $$aAnderson, Kristin$$b30
000167638 7001_ $$aArnau-Collell, Coral$$b31
000167638 7001_ $$0P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aArndt, Volker$$b32$$udkfz
000167638 7001_ $$aBanbury, Barbara L$$b33
000167638 7001_ $$aBassik, Michael C$$b34
000167638 7001_ $$aBerndt, Sonja I$$b35
000167638 7001_ $$aBézieau, Stéphane$$b36
000167638 7001_ $$aBishop, D Timothy$$b37
000167638 7001_ $$aBoehm, Juergen$$b38
000167638 7001_ $$aBoeing, Heiner$$b39
000167638 7001_ $$aBoutron-Ruault, Marie-Christine$$b40
000167638 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b41$$udkfz
000167638 7001_ $$aBrezina, Stefanie$$b42
000167638 7001_ $$aBuch, Stephan$$b43
000167638 7001_ $$00000-0003-2225-6675$$aBuchanan, Daniel D$$b44
000167638 7001_ $$aBurnett-Hartman, Andrea$$b45
000167638 7001_ $$aCaan, Bette J$$b46
000167638 7001_ $$aCampbell, Peter T$$b47
000167638 7001_ $$0P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107$$aCarr, Prudence R$$b48$$udkfz
000167638 7001_ $$aCastells, Antoni$$b49
000167638 7001_ $$aCastellví-Bel, Sergi$$b50
000167638 7001_ $$00000-0001-7284-6767$$aChan, Andrew T$$b51
000167638 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b52$$udkfz
000167638 7001_ $$aChanock, Stephen J$$b53
000167638 7001_ $$aCurtis, Keith R$$b54
000167638 7001_ $$ade la Chapelle, Albert$$b55
000167638 7001_ $$aEaston, Douglas F$$b56
000167638 7001_ $$aEnglish, Dallas R$$b57
000167638 7001_ $$aFeskens, Edith J M$$b58
000167638 7001_ $$aGala, Manish$$b59
000167638 7001_ $$aGallinger, Steven J$$b60
000167638 7001_ $$aGauderman, W James$$b61
000167638 7001_ $$aGiles, Graham G$$b62
000167638 7001_ $$aGoodman, Phyllis J$$b63
000167638 7001_ $$aGrady, William M$$b64
000167638 7001_ $$aGrove, John S$$b65
000167638 7001_ $$00000-0002-9795-1528$$aGsur, Andrea$$b66
000167638 7001_ $$aGunter, Marc J$$b67
000167638 7001_ $$aHaile, Robert W$$b68
000167638 7001_ $$00000-0002-2421-6127$$aHampe, Jochen$$b69
000167638 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b70$$udkfz
000167638 7001_ $$aHopper, John L$$b71
000167638 7001_ $$aHsu, Wan-Ling$$b72
000167638 7001_ $$aHuang, Wen-Yi$$b73
000167638 7001_ $$aHudson, Thomas J$$b74
000167638 7001_ $$00000-0002-0573-1852$$aJenab, Mazda$$b75
000167638 7001_ $$aJenkins, Mark A$$b76
000167638 7001_ $$aJoshi, Amit D$$b77
000167638 7001_ $$aKeku, Temitope O$$b78
000167638 7001_ $$aKooperberg, Charles$$b79
000167638 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b80$$udkfz
000167638 7001_ $$aKüry, Sébastien$$b81
000167638 7001_ $$aLe Marchand, Loic$$b82
000167638 7001_ $$aLejbkowicz, Flavio$$b83
000167638 7001_ $$aLi, Christopher I$$b84
000167638 7001_ $$aLi, Li$$b85
000167638 7001_ $$aLieb, Wolfgang$$b86
000167638 7001_ $$aLindblom, Annika$$b87
000167638 7001_ $$aLindor, Noralane M$$b88
000167638 7001_ $$aMännistö, Satu$$b89
000167638 7001_ $$aMarkowitz, Sanford D$$b90
000167638 7001_ $$aMilne, Roger L$$b91
000167638 7001_ $$aMoreno, Lorena$$b92
000167638 7001_ $$00000-0003-3347-8249$$aMurphy, Neil$$b93
000167638 7001_ $$aNassir, Rami$$b94
000167638 7001_ $$aOffit, Kenneth$$b95
000167638 7001_ $$aOgino, Shuji$$b96
000167638 7001_ $$aPanico, Salvatore$$b97
000167638 7001_ $$aParfrey, Patrick S$$b98
000167638 7001_ $$aPearlman, Rachel$$b99
000167638 7001_ $$aPharoah, Paul D P$$b100
000167638 7001_ $$aPhipps, Amanda I$$b101
000167638 7001_ $$aPlatz, Elizabeth A$$b102
000167638 7001_ $$aPotter, John D$$b103
000167638 7001_ $$aPrentice, Ross L$$b104
000167638 7001_ $$aQi, Lihong$$b105
000167638 7001_ $$aRaskin, Leon$$b106
000167638 7001_ $$aRennert, Gad$$b107
000167638 7001_ $$aRennert, Hedy S$$b108
000167638 7001_ $$aRiboli, Elio$$b109
000167638 7001_ $$aSchafmayer, Clemens$$b110
000167638 7001_ $$aSchoen, Robert E$$b111
000167638 7001_ $$aSeminara, Daniela$$b112
000167638 7001_ $$aSong, Mingyang$$b113
000167638 7001_ $$aSu, Yu-Ru$$b114
000167638 7001_ $$aTangen, Catherine M$$b115
000167638 7001_ $$aThibodeau, Stephen N$$b116
000167638 7001_ $$aThomas, Duncan C$$b117
000167638 7001_ $$aTrichopoulou, Antonia$$b118
000167638 7001_ $$aUlrich, Cornelia M$$b119
000167638 7001_ $$aVisvanathan, Kala$$b120
000167638 7001_ $$aVodicka, Pavel$$b121
000167638 7001_ $$aVodickova, Ludmila$$b122
000167638 7001_ $$aVymetalkova, Veronika$$b123
000167638 7001_ $$0P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aWeigl, Korbinian$$b124$$udkfz
000167638 7001_ $$aWeinstein, Stephanie J$$b125
000167638 7001_ $$aWhite, Emily$$b126
000167638 7001_ $$aWolk, Alicja$$b127
000167638 7001_ $$aWoods, Michael O$$b128
000167638 7001_ $$aWu, Anna H$$b129
000167638 7001_ $$aAbecasis, Goncalo R$$b130
000167638 7001_ $$aNickerson, Deborah A$$b131
000167638 7001_ $$aScacheri, Peter C$$b132
000167638 7001_ $$aKundaje, Anshul$$b133
000167638 7001_ $$aCasey, Graham$$b134
000167638 7001_ $$aGruber, Stephen B$$b135
000167638 7001_ $$aHsu, Li$$b136
000167638 7001_ $$aMoreno, Victor$$b137
000167638 7001_ $$aHayes, Richard B$$b138
000167638 7001_ $$aNewcomb, Polly A$$b139
000167638 7001_ $$00000-0001-5666-9318$$aPeters, Ulrike$$b140
000167638 773__ $$0PERI:(DE-600)1492637-4$$a10.1136/gutjnl-2020-321534$$gp. gutjnl-2020-321534 -$$n7$$p1325-1334$$tGut$$v70$$x1468-3288$$y2021
000167638 909CO $$ooai:inrepo02.dkfz.de:167638$$pVDB
000167638 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aDeutsches Krebsforschungszentrum$$b32$$kDKFZ
000167638 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aDeutsches Krebsforschungszentrum$$b41$$kDKFZ
000167638 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)7d7ee36ed0313bbc4c91bc3df5950107$$aDeutsches Krebsforschungszentrum$$b48$$kDKFZ
000167638 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aDeutsches Krebsforschungszentrum$$b52$$kDKFZ
000167638 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aDeutsches Krebsforschungszentrum$$b70$$kDKFZ
000167638 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aDeutsches Krebsforschungszentrum$$b80$$kDKFZ
000167638 9101_ $$0I:(DE-588b)2036810-0$$6P:(DE-He78)f4e98340e600f7411886c21c7b778d36$$aDeutsches Krebsforschungszentrum$$b124$$kDKFZ
000167638 9130_ $$0G:(DE-HGF)POF3-313$$1G:(DE-HGF)POF3-310$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vCancer risk factors and prevention$$x0
000167638 9131_ $$0G:(DE-HGF)POF4-313$$1G:(DE-HGF)POF4-310$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lKrebsforschung$$vKrebsrisikofaktoren und Prävention$$x0
000167638 9141_ $$y2021
000167638 915__ $$0StatID:(DE-HGF)0410$$2StatID$$aAllianz-Lizenz$$d2020-09-04$$wger
000167638 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2020-09-04$$wger
000167638 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bGUT : 2018$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2020-09-04
000167638 915__ $$0StatID:(DE-HGF)9915$$2StatID$$aIF >= 15$$bGUT : 2018$$d2020-09-04
000167638 9201_ $$0I:(DE-He78)C070-20160331$$kC070$$lC070 Klinische Epidemiologie und Alternf.$$x0
000167638 9201_ $$0I:(DE-He78)C120-20160331$$kC120$$lPräventive Onkologie$$x1
000167638 9201_ $$0I:(DE-He78)HD01-20160331$$kHD01$$lDKTK HD zentral$$x2
000167638 9201_ $$0I:(DE-He78)C020-20160331$$kC020$$lC020 Epidemiologie von Krebs$$x3
000167638 980__ $$ajournal
000167638 980__ $$aVDB
000167638 980__ $$aI:(DE-He78)C070-20160331
000167638 980__ $$aI:(DE-He78)C120-20160331
000167638 980__ $$aI:(DE-He78)HD01-20160331
000167638 980__ $$aI:(DE-He78)C020-20160331
000167638 980__ $$aUNRESTRICTED