TY  - JOUR
AU  - Chen, Xuechen
AU  - Jansen, Lina
AU  - Guo, Feng
AU  - Hoffmeister, Michael
AU  - Chang-Claude, Jenny
AU  - Brenner, Hermann
TI  - Smoking, Genetic Predisposition, and Colorectal Cancer Risk.
JO  - Clinical and translational gastroenterology
VL  - 12
IS  - 3
SN  - 2155-384X
CY  - London
PB  - Nature Publ. Group
M1  - DKFZ-2021-00502
SP  - e00317
PY  - 2021
N1  - #EA:C070#LA:C070#2021 Mar 1;12(3):e00317
AB  - Smoking and genetic predisposition are established risk factors for colorectal cancer (CRC). We aimed to assess and compare their individual and joint impact on CRC risk using the novel approach of genetic risk equivalent (GRE).Data were extracted from the Darmkrebs: Chancen der Verhütung durch Screening study, a large population-based case-control study in Germany. A polygenic risk score (PRS) based on 140 CRC-related single nucleotide polymorphisms was derived to quantify genetic risk. Multiple logistic regression was used to estimate the individual and joint impact of smoking and PRS on CRC risk, and to quantify the smoking effect in terms of GRE, the corresponding effect conveyed by a defined difference in PRS percentiles.There were 5,086 patients with CRC and 4,120 controls included. Current smokers had a 48
LB  - PUB:(DE-HGF)16
C6  - pmid:33646204
DO  - DOI:10.14309/ctg.0000000000000317
UR  - https://inrepo02.dkfz.de/record/167736
ER  -