TY  - JOUR
AU  - Guo, Feng
AU  - Chen, Xuechen
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - Colorectal Cancer Risk by Genetic Variants in Populations With and Without Colonoscopy History.
JO  - JNCI cancer spectrum
VL  - 5
IS  - 1
SN  - 2515-5091
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2021-00517
SP  - pkab008
PY  - 2021
N1  - #EA:C070#LA:C070#
AB  - Polygenic risk scores (PRS), which are derived from results of large genome-wide association studies, are increasingly propagated for colorectal cancer (CRC) risk stratification. The majority of studies included in the large genome-wide association studies consortia were conducted in the United States and Germany, where colonoscopy with detection and removal of polyps has been widely practiced over the last decades. We aimed to assess if and to what extent the history of colonoscopy with polypectomy may alter metrics of the predictive ability of PRS for CRC risk.A PRS based on 140 single nucleotide polymorphisms was compared between 4939 CRC patients and 3797 control persons of the Darmkrebs: Chancen der Verhütung durch Screening (DACHS) study, a population-based case-control study conducted in Germany. Risk discrimination was quantified according to the history of colonoscopy and polypectomy by areas under the curves (AUCs) and their 95
LB  - PUB:(DE-HGF)16
C6  - pmid:33644683
C2  - pmc:PMC7898082
DO  - DOI:10.1093/jncics/pkab008
UR  - https://inrepo02.dkfz.de/record/167753
ER  -