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@ARTICLE{Guo:167753,
      author       = {F. Guo$^*$ and X. Chen$^*$ and J. Chang-Claude$^*$ and M.
                      Hoffmeister$^*$ and H. Brenner$^*$},
      title        = {{C}olorectal {C}ancer {R}isk by {G}enetic {V}ariants in
                      {P}opulations {W}ith and {W}ithout {C}olonoscopy {H}istory.},
      journal      = {JNCI cancer spectrum},
      volume       = {5},
      number       = {1},
      issn         = {2515-5091},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-00517},
      pages        = {pkab008},
      year         = {2021},
      note         = {#EA:C070#LA:C070#},
      abstract     = {Polygenic risk scores (PRS), which are derived from results
                      of large genome-wide association studies, are increasingly
                      propagated for colorectal cancer (CRC) risk stratification.
                      The majority of studies included in the large genome-wide
                      association studies consortia were conducted in the United
                      States and Germany, where colonoscopy with detection and
                      removal of polyps has been widely practiced over the last
                      decades. We aimed to assess if and to what extent the
                      history of colonoscopy with polypectomy may alter metrics of
                      the predictive ability of PRS for CRC risk.A PRS based on
                      140 single nucleotide polymorphisms was compared between
                      4939 CRC patients and 3797 control persons of the
                      Darmkrebs: Chancen der Verhütung durch Screening (DACHS)
                      study, a population-based case-control study conducted in
                      Germany. Risk discrimination was quantified according to the
                      history of colonoscopy and polypectomy by areas under the
                      curves (AUCs) and their $95\%$ confidence intervals (CIs).
                      All statistical tests were 2-sided.AUCs and $95\%$ CIs were
                      higher among subjects without previous colonoscopy (AUC =
                      0.622, $95\%$ CI = 0.606 to 0.639) than among those with
                      previous colonoscopy and polypectomy (AUC = 0.568, $95\%$ CI
                      = 0.536 to 0.601; difference [Δ AUC] = 0.054, P = .004).
                      Such differences were consistently seen in sex-specific
                      groups (women: Δ AUC = 0.073, P = .02; men: Δ AUC = 0.046,
                      P = .048) and age-specific groups (younger than 70 years: Δ
                      AUC = 0.052, P = .07; 70 years or older: Δ AUC = 0.049, P =
                      .045).Predictive performance of PRS may be underestimated in
                      populations with widespread use of colonoscopy. Future
                      studies using PRS to develop CRC prediction models should
                      carefully consider colonoscopy history to provide more
                      accurate estimates.},
      cin          = {C070 / C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33644683},
      pmc          = {pmc:PMC7898082},
      doi          = {10.1093/jncics/pkab008},
      url          = {https://inrepo02.dkfz.de/record/167753},
}