%0 Journal Article
%A Dimou, Niki
%A Yarmolinsky, James
%A Bouras, Emmanouil
%A Tsilidis, Konstantinos K
%A Martin, Richard M
%A Lewis, Sarah J
%A Gram, Inger T
%A Bakker, Marije F
%A Brenner, Hermann
%A Figueiredo, Jane C
%A Turzanski-Fortner, Renée
%A Gruber, Stephen B
%A Van Guelpen, Bethany
%A Hsu, Li
%A Kaaks, Rudolf
%A Kweon, Sun-Seog
%A Lin, Yi
%A Lindor, Noralane M
%A Newcomb, Polly A
%A Sanchez-Perez, Maria-Jose
%A Severi, Gianluca
%A Tindle, Hilary A
%A Tumino, Rosario
%A Weiderpass, Elisabete
%A Gunter, Marc J
%A Murphy, Neil
%T Causal effects of lifetime smoking on breast and colorectal cancer risk: Mendelian randomization study.
%J Cancer epidemiology, biomarkers & prevention
%V 30
%N 5
%@ 1538-7755
%C Philadelphia, Pa.
%I AACR
%M DKFZ-2021-00533
%P 953-964
%D 2021
%Z 30(5):953-964
%X Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and colorectal cancer.Genome-wide association study summary data were used to identify genetic variants associated with lifetime amount of smoking (n=126 variants) and ever having smoked regularly (n=112 variants). Using two-sample MR, we examined these variants in relation to incident breast (122,977 cases/105,974 controls) and colorectal cancer (52,775 cases/45,940 controls).In inverse-variance weighted models, a genetic predisposition to higher lifetime amount of smoking was positively associated with breast cancer risk [odds ratio [OR] per 1-standard deviation (SD) increment: 1.13 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33653810
%R 10.1158/1055-9965.EPI-20-1218
%U https://inrepo02.dkfz.de/record/167769