TY  - JOUR
AU  - Dimou, Niki
AU  - Yarmolinsky, James
AU  - Bouras, Emmanouil
AU  - Tsilidis, Konstantinos K
AU  - Martin, Richard M
AU  - Lewis, Sarah J
AU  - Gram, Inger T
AU  - Bakker, Marije F
AU  - Brenner, Hermann
AU  - Figueiredo, Jane C
AU  - Turzanski-Fortner, Renée
AU  - Gruber, Stephen B
AU  - Van Guelpen, Bethany
AU  - Hsu, Li
AU  - Kaaks, Rudolf
AU  - Kweon, Sun-Seog
AU  - Lin, Yi
AU  - Lindor, Noralane M
AU  - Newcomb, Polly A
AU  - Sanchez-Perez, Maria-Jose
AU  - Severi, Gianluca
AU  - Tindle, Hilary A
AU  - Tumino, Rosario
AU  - Weiderpass, Elisabete
AU  - Gunter, Marc J
AU  - Murphy, Neil
TI  - Causal effects of lifetime smoking on breast and colorectal cancer risk: Mendelian randomization study.
JO  - Cancer epidemiology, biomarkers & prevention
VL  - 30
IS  - 5
SN  - 1538-7755
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2021-00533
SP  - 953-964
PY  - 2021
N1  - 30(5):953-964
AB  - Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and colorectal cancer.Genome-wide association study summary data were used to identify genetic variants associated with lifetime amount of smoking (n=126 variants) and ever having smoked regularly (n=112 variants). Using two-sample MR, we examined these variants in relation to incident breast (122,977 cases/105,974 controls) and colorectal cancer (52,775 cases/45,940 controls).In inverse-variance weighted models, a genetic predisposition to higher lifetime amount of smoking was positively associated with breast cancer risk [odds ratio [OR] per 1-standard deviation (SD) increment: 1.13 (95
LB  - PUB:(DE-HGF)16
C6  - pmid:33653810
DO  - DOI:10.1158/1055-9965.EPI-20-1218
UR  - https://inrepo02.dkfz.de/record/167769
ER  -