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000167785 0247_ $$2doi$$a10.1093/ajcn/nqaa422
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000167785 0247_ $$2ISSN$$a0095-9871
000167785 0247_ $$2ISSN$$a1938-3207
000167785 0247_ $$2ISSN$$a1938-3215
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000167785 041__ $$aEnglish
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000167785 1001_ $$aKoole, Janna L$$b0
000167785 245__ $$aCirculating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal cancer: results from the FOCUS consortium.
000167785 260__ $$aOxford$$bOxford University Press$$c2021
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000167785 520__ $$aB vitamins have been associated with the risk and progression of colorectal cancer (CRC), given their central roles in nucleotide synthesis and methylation, yet their association with quality of life in established CRC is unclear.To investigate whether quality of life 6 months postdiagnosis is associated with: 1) circulating concentrations of B vitamins and related biomarkers 6 months postdiagnosis; 2) changes in these concentrations between diagnosis and 6 months postdiagnosis; 3) B-vitamin supplement use 6 months postdiagnosis; and 4) changes in B-vitamin supplement use between diagnosis and 6 months postdiagnosis.We included 1676 newly diagnosed stage I-III CRC patients from 3 prospective European cohorts. Circulating concentrations of 9 biomarkers related to the B vitamins folate, riboflavin, vitamin B6, and cobalamin were measured at diagnosis and 6 months postdiagnosis. Information on dietary supplement use was collected at both time points. Health-related quality of life (global quality of life, functioning scales, and fatigue) was assessed by the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire 6 months postdiagnosis. Confounder-adjusted linear regression analyses were performed, adjusted for multiple testing.Higher pyridoxal 5'-phosphate (PLP) was cross-sectionally associated with better physical, role, and social functioning, as well as reduced fatigue, 6 months postdiagnosis. Associations were observed for a doubling in the hydroxykynurenine ratio [3-hydroxykynurenine: (kynurenic acid + xanthurenic acid + 3-hydroxyanthranilic acid + anthranilic acid); an inverse marker of vitamin B6] and both reduced global quality of life (β = -3.62; 95% CI: -5.88, -1.36) and worse physical functioning (β = -5.01; 95% CI: -7.09, -2.94). Dose-response relations were observed for PLP and quality of life. No associations were observed for changes in biomarker concentrations between diagnosis and 6 months. Participants who stopped using B-vitamin supplements after diagnosis reported higher fatigue than nonusers.Higher vitamin B6 status was associated with better quality of life, yet limited associations were observed for the use of B-vitamin supplements. Vitamin B6 needs further study to clarify its role in relation to quality of life.
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000167785 650_7 $$2Other$$aB vitamins
000167785 650_7 $$2Other$$abiomarkers
000167785 650_7 $$2Other$$acolorectal cancer
000167785 650_7 $$2Other$$adietary supplement use
000167785 650_7 $$2Other$$afatigue
000167785 650_7 $$2Other$$afolates
000167785 650_7 $$2Other$$afunctioning
000167785 650_7 $$2Other$$ahealth-related quality of life
000167785 650_7 $$2Other$$apyridoxal 5′-phosphate
000167785 650_7 $$2Other$$avitamin B6
000167785 7001_ $$aBours, Martijn J L$$b1
000167785 7001_ $$aGeijsen, Anne J M R$$b2
000167785 7001_ $$aGigic, Biljana$$b3
000167785 7001_ $$aUlvik, Arve$$b4
000167785 7001_ $$aKok, Dieuwertje E$$b5
000167785 7001_ $$aBrezina, Stefanie$$b6
000167785 7001_ $$aOse, Jennifer$$b7
000167785 7001_ $$aBaierl, Andreas$$b8
000167785 7001_ $$aBöhm, Jürgen$$b9
000167785 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b10$$udkfz
000167785 7001_ $$aBreukink, Stéphanie O$$b11
000167785 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b12$$udkfz
000167785 7001_ $$avan Duijnhoven, Fränzel J B$$b13
000167785 7001_ $$avan Duijvendijk, Peter$$b14
000167785 7001_ $$aGumpenberger, Tanja$$b15
000167785 7001_ $$aHabermann, Nina$$b16
000167785 7001_ $$avan Halteren, Henk K$$b17
000167785 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b18$$udkfz
000167785 7001_ $$aHolowatyj, Andreana N$$b19
000167785 7001_ $$aJanssen-Heijnen, Maryska L G$$b20
000167785 7001_ $$aKeulen, Eric T P$$b21
000167785 7001_ $$aKiblawi, Rama$$b22
000167785 7001_ $$aKruyt, Flip M$$b23
000167785 7001_ $$aLi, Christopher I$$b24
000167785 7001_ $$aLin, Tengda$$b25
000167785 7001_ $$aMidttun, Øivind$$b26
000167785 7001_ $$aPeoples, Anita R$$b27
000167785 7001_ $$avan Roekel, Eline H$$b28
000167785 7001_ $$aSchneider, Martin A$$b29
000167785 7001_ $$0P:(DE-He78)01ef71f71b01a3ec3b698653fd43fe86$$aSchrotz-King, Petra$$b30$$udkfz
000167785 7001_ $$aUlrich, Alexis B$$b31
000167785 7001_ $$aVickers, Kathy$$b32
000167785 7001_ $$aWesselink, Evertine$$b33
000167785 7001_ $$ade Wilt, Johannes H W$$b34
000167785 7001_ $$aGsur, Andrea$$b35
000167785 7001_ $$aUeland, Per M$$b36
000167785 7001_ $$aUlrich, Cornelia M$$b37
000167785 7001_ $$aKampman, Ellen$$b38
000167785 7001_ $$aWeijenberg, Matty P$$b39
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