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@ARTICLE{Koole:167785,
      author       = {J. L. Koole and M. J. L. Bours and A. J. M. R. Geijsen and
                      B. Gigic and A. Ulvik and D. E. Kok and S. Brezina and J.
                      Ose and A. Baierl and J. Böhm and H. Brenner$^*$ and S. O.
                      Breukink and J. Chang-Claude$^*$ and F. J. B. van Duijnhoven
                      and P. van Duijvendijk and T. Gumpenberger and N. Habermann
                      and H. K. van Halteren and M. Hoffmeister$^*$ and A. N.
                      Holowatyj and M. L. G. Janssen-Heijnen and E. T. P. Keulen
                      and R. Kiblawi and F. M. Kruyt and C. I. Li and T. Lin and
                      Ø. Midttun and A. R. Peoples and E. H. van Roekel and M. A.
                      Schneider and P. Schrotz-King$^*$ and A. B. Ulrich and K.
                      Vickers and E. Wesselink and J. H. W. de Wilt and A. Gsur
                      and P. M. Ueland and C. M. Ulrich and E. Kampman and M. P.
                      Weijenberg},
      title        = {{C}irculating {B}-vitamin biomarkers and {B}-vitamin
                      supplement use in relation to quality of life in patients
                      with colorectal cancer: results from the {FOCUS}
                      consortium.},
      journal      = {The American journal of clinical nutrition},
      volume       = {113},
      number       = {6},
      issn         = {1938-3207},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-00547},
      pages        = {1468-1481},
      year         = {2021},
      note         = {113(6):1468-1481},
      abstract     = {B vitamins have been associated with the risk and
                      progression of colorectal cancer (CRC), given their central
                      roles in nucleotide synthesis and methylation, yet their
                      association with quality of life in established CRC is
                      unclear.To investigate whether quality of life 6 months
                      postdiagnosis is associated with: 1) circulating
                      concentrations of B vitamins and related biomarkers 6 months
                      postdiagnosis; 2) changes in these concentrations between
                      diagnosis and 6 months postdiagnosis; 3) B-vitamin
                      supplement use 6 months postdiagnosis; and 4) changes in
                      B-vitamin supplement use between diagnosis and 6 months
                      postdiagnosis.We included 1676 newly diagnosed stage I-III
                      CRC patients from 3 prospective European cohorts.
                      Circulating concentrations of 9 biomarkers related to the B
                      vitamins folate, riboflavin, vitamin B6, and cobalamin were
                      measured at diagnosis and 6 months postdiagnosis.
                      Information on dietary supplement use was collected at both
                      time points. Health-related quality of life (global quality
                      of life, functioning scales, and fatigue) was assessed by
                      the European Organisation for Research and Treatment of
                      Cancer Quality of Life Questionnaire 6 months postdiagnosis.
                      Confounder-adjusted linear regression analyses were
                      performed, adjusted for multiple testing.Higher pyridoxal
                      5'-phosphate (PLP) was cross-sectionally associated with
                      better physical, role, and social functioning, as well as
                      reduced fatigue, 6 months postdiagnosis. Associations were
                      observed for a doubling in the hydroxykynurenine ratio
                      [3-hydroxykynurenine: (kynurenic acid + xanthurenic
                      acid + 3-hydroxyanthranilic acid + anthranilic acid); an
                      inverse marker of vitamin B6] and both reduced global
                      quality of life (β = -3.62; $95\%$ CI: -5.88, -1.36) and
                      worse physical functioning (β = -5.01; $95\%$ CI: -7.09,
                      -2.94). Dose-response relations were observed for PLP and
                      quality of life. No associations were observed for changes
                      in biomarker concentrations between diagnosis and 6 months.
                      Participants who stopped using B-vitamin supplements after
                      diagnosis reported higher fatigue than nonusers.Higher
                      vitamin B6 status was associated with better quality of
                      life, yet limited associations were observed for the use of
                      B-vitamin supplements. Vitamin B6 needs further study to
                      clarify its role in relation to quality of life.},
      keywords     = {B vitamins (Other) / biomarkers (Other) / colorectal cancer
                      (Other) / dietary supplement use (Other) / fatigue (Other) /
                      folates (Other) / functioning (Other) / health-related
                      quality of life (Other) / pyridoxal 5′-phosphate (Other) /
                      vitamin B6 (Other)},
      cin          = {C070 / HD01 / C020 / C120},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)HD01-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33668069},
      doi          = {10.1093/ajcn/nqaa422},
      url          = {https://inrepo02.dkfz.de/record/167785},
}