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000167786 1001_ $$aMaurer, T.$$b0
000167786 245__ $$aTired of feeling tired - The role of circulating inflammatory biomarkers and long-term cancer related fatigue in breast cancer survivors.
000167786 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2021
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000167786 520__ $$aLow-grade inflammation has been associated with cancer related fatigue (CRF). However, most studies focused on CRF during or shortly after treatment. Longitudinal studies are rare with inconsistent results. We assessed the association of inflammatory biomarkers with total CRF and all subdomains (physical, cognitive, affective) in long-term breast cancer survivors.Patients recruited between 2002 and 2005 provided information on CRF at first follow-up (FU1) (N = 1292) and second follow-up (FU2) (N = 1205), after a median of 6.2 years and 11.7 years, respectively. Associations of 11 inflammatory biomarkers with CRF at FU1 and at FU2 were assessed using linear regression models. Logistic regression models were used to compare patients fatigued at both time-points and those never fatigued (N = 932).C-reactive protein (CRP) was significantly associated with total CRF at FU1 (β = 1.47, 95%CI = 0.62-2.31, p = 0.0007), at FU2 (β = 1.98, 95 %CI = 0.96-2.99, p = 0.0001) and with persistent CRF (OR = 1.29, 95%CI = 1.13-1.47, p < 0.0001). IL-6 levels were associated with total CRF at FU1 (β = 1.01, 95%CI = 0.43-1.59, p = 0.0006), but not with CRF at FU2 or persistent CRF. No association remained significant after adjustment for relevant covariates.CRP and Il-6 were associated with risk of CRF in long-term breast cancer survivors, but were not independent of other known risk factors, suggesting that currently studied inflammatory markers are not suitable to identify patients at risk of long-term CRF.
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000167786 650_7 $$2Other$$aBreast cancer
000167786 650_7 $$2Other$$aCancer
000167786 650_7 $$2Other$$aCancer related fatigue
000167786 650_7 $$2Other$$aCytokines
000167786 650_7 $$2Other$$aFatigue
000167786 650_7 $$2Other$$aImmune system
000167786 650_7 $$2Other$$aInflammation
000167786 650_7 $$2Other$$aLifestyle
000167786 650_7 $$2Other$$aQuality of life
000167786 7001_ $$0P:(DE-He78)e16e2a17f7dd2e7f7e917c0382f19b2d$$aJaskulski, Stefanie$$b1
000167786 7001_ $$0P:(DE-He78)6b04712f3afe72044d496a25505cb1ea$$aBehrens, S.$$b2$$udkfz
000167786 7001_ $$0P:(DE-He78)bce1fdec5ce564e2666156d96aeabec9$$aJung, A. Y.$$b3$$udkfz
000167786 7001_ $$aObi, N.$$b4
000167786 7001_ $$0P:(DE-He78)79ab945544e5bc017a2317b6146ed3aa$$aJohnson, T.$$b5$$udkfz
000167786 7001_ $$aBecher, H.$$b6
000167786 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b7$$eLast author$$udkfz
000167786 773__ $$0PERI:(DE-600)2009043-2$$a10.1016/j.breast.2021.02.008$$gVol. 56, p. 103 - 109$$p103 - 109$$tThe breast$$v56$$x0960-9776$$y2021
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