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@ARTICLE{Maurer:167786,
      author       = {T. Maurer and S. Jaskulski$^*$ and S. Behrens$^*$ and A. Y.
                      Jung$^*$ and N. Obi and T. Johnson$^*$ and H. Becher and J.
                      Chang-Claude$^*$},
      title        = {{T}ired of feeling tired - {T}he role of circulating
                      inflammatory biomarkers and long-term cancer related fatigue
                      in breast cancer survivors.},
      journal      = {The breast},
      volume       = {56},
      issn         = {0960-9776},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-00548},
      pages        = {103 - 109},
      year         = {2021},
      note         = {#LA:C020#},
      abstract     = {Low-grade inflammation has been associated with cancer
                      related fatigue (CRF). However, most studies focused on CRF
                      during or shortly after treatment. Longitudinal studies are
                      rare with inconsistent results. We assessed the association
                      of inflammatory biomarkers with total CRF and all subdomains
                      (physical, cognitive, affective) in long-term breast cancer
                      survivors.Patients recruited between 2002 and 2005 provided
                      information on CRF at first follow-up (FU1) (N = 1292) and
                      second follow-up (FU2) (N = 1205), after a median of 6.2
                      years and 11.7 years, respectively. Associations of 11
                      inflammatory biomarkers with CRF at FU1 and at FU2 were
                      assessed using linear regression models. Logistic regression
                      models were used to compare patients fatigued at both
                      time-points and those never fatigued (N = 932).C-reactive
                      protein (CRP) was significantly associated with total CRF at
                      FU1 (β = 1.47, $95\%CI = 0.62-2.31,$ p = 0.0007), at
                      FU2 (β = 1.98, 95 $\%CI = 0.96-2.99,$ p = 0.0001) and
                      with persistent CRF (OR = 1.29, $95\%CI = 1.13-1.47,$
                      p < 0.0001). IL-6 levels were associated with total CRF at
                      FU1 (β = 1.01, $95\%CI = 0.43-1.59,$ p = 0.0006), but
                      not with CRF at FU2 or persistent CRF. No association
                      remained significant after adjustment for relevant
                      covariates.CRP and Il-6 were associated with risk of CRF in
                      long-term breast cancer survivors, but were not independent
                      of other known risk factors, suggesting that currently
                      studied inflammatory markers are not suitable to identify
                      patients at risk of long-term CRF.},
      keywords     = {Breast cancer (Other) / Cancer (Other) / Cancer related
                      fatigue (Other) / Cytokines (Other) / Fatigue (Other) /
                      Immune system (Other) / Inflammation (Other) / Lifestyle
                      (Other) / Quality of life (Other)},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33668004},
      doi          = {10.1016/j.breast.2021.02.008},
      url          = {https://inrepo02.dkfz.de/record/167786},
}