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@ARTICLE{RuizPrez:167797,
      author       = {M. V. Ruiz-Pérez and L. Sainero-Alcolado and G. Oliynyk
                      and I. Matuschek and N. Balboni and S. J. K. A. Ubhayasekera
                      and M. T. Snaebjornsson$^*$ and K. Makowski and K. Aaltonen
                      and D. Bexell and D. Serra and R. Nilsson and J. Bergquist
                      and A. Schulze$^*$ and M. Arsenian-Henriksson},
      title        = {{I}nhibition of fatty acid synthesis induces
                      differentiation and reduces tumor burden in childhood
                      neuroblastoma.},
      journal      = {iScience},
      volume       = {24},
      number       = {2},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2021-00559},
      pages        = {102128},
      year         = {2021},
      abstract     = {Many metabolic pathways, including lipid metabolism, are
                      rewired in tumors to support energy and biomass production
                      and to allow adaptation to stressful environments.
                      Neuroblastoma is the second deadliest solid tumor in
                      children. Genetic aberrations, as the amplification of the
                      MYCN-oncogene, correlate strongly with disease progression.
                      Yet, there are only a few molecular targets successfully
                      exploited in the clinic. Here we show that inhibition of
                      fatty acid synthesis led to increased neural differentiation
                      and reduced tumor burden in neuroblastoma xenograft
                      experiments independently of MYCN-status. This was
                      accompanied by reduced levels of the MYCN or c-MYC
                      oncoproteins and activation of ERK signaling. Importantly,
                      the expression levels of genes involved in de novo fatty
                      acid synthesis showed prognostic value for neuroblastoma
                      patients. Our findings demonstrate that inhibition of de
                      novo fatty acid synthesis is a promising pharmacological
                      intervention strategy for the treatment of neuroblastoma
                      independently of MYCN-status.},
      keywords     = {biological sciences (Other) / cancer (Other) / cell biology
                      (Other) / molecular biology (Other)},
      cin          = {A410},
      ddc          = {050},
      cid          = {I:(DE-He78)A410-20160331},
      pnm          = {311 - Zellbiologie und Tumorbiologie (POF4-311)},
      pid          = {G:(DE-HGF)POF4-311},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33659885},
      pmc          = {pmc:PMC7895756},
      doi          = {10.1016/j.isci.2021.102128},
      url          = {https://inrepo02.dkfz.de/record/167797},
}