Home > Publications database > Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions. > print

001     167919
005     20240229133554.0
024 7 _ |a 10.1073/pnas.2025830118
|2 doi
024 7 _ |a pmid:33723077
|2 pmid
024 7 _ |a 0027-8424
|2 ISSN
024 7 _ |a 1091-6490
|2 ISSN
024 7 _ |a altmetric:101700394
|2 altmetric
037 _ _ |a DKFZ-2021-00638
041 _ _ |a English
082 _ _ |a 500
100 1 _ |a Bund, Timo
|0 P:(DE-He78)42946c81b039c802769d91e486a4d5fb
|b 0
|e First author
|u dkfz
245 _ _ |a Analysis of chronic inflammatory lesions of the colon for BMMF Rep antigen expression and CD68 macrophage interactions.
260 _ _ |a Washington, DC
|c 2021
|b National Acad. of Sciences
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1616510196_6687
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
500 _ _ |a #EA:F200#LA:F200#
520 _ _ |a Consumption of Eurasian bovine meat and milk has been associated with cancer development, in particular with colorectal cancer (CRC). In addition, zoonotic infectious agents from bovine products were proposed to cause colon cancer (zur Hausen et al., 2009). Bovine meat and milk factors (BMMF) are small episomal DNA molecules frequently isolated from bovine sera and milk products, and recently, also from colon cancer (de Villiers et al., 2019). BMMF are bioactive in human cells and were proposed to induce chronic inflammation in precancerous tissue leading to increased radical formation: for example, reactive oxygen and reactive nitrogen species and elevated levels of DNA mutations in replicating cells, such as cancer progenitor cells (zur Hausen et al., 2018). Mouse monoclonal antibodies against the replication (Rep) protein of H1MSB.1 (BMMF1) were used to analyze BMMF presence in different cohorts of CRC peritumor and tumor tissues and cancer-free individuals by immunohistochemistry and Western blot. BMMF DNA was isolated by laser microdissection from immunohistochemistry-positive tissue regions. We found BMMF Rep protein present specifically in close vicinity of CD68+ macrophages in the interstitial lamina propria adjacent to CRC tissues, suggesting the presence of local chronic inflammation. BMMF1 (modified H1MSB.1) DNA was isolated from the same tissue regions. Rep and CD68+ detection increased significantly in peritumor cancer tissues when compared to tissues of cancer-free individuals. This strengthens previous postulations that BMMF function as indirect carcinogens by inducing chronic inflammation and DNA damage in replicating cells, which represent progress to progenitor cells for adenoma (polyps) formation and cancer.
536 _ _ |a 316 - Infektionen, Entzündung und Krebs (POF4-316)
|0 G:(DE-HGF)POF4-316
|c POF4-316
|x 0
|f POF IV
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a BMMF
|2 Other
650 _ 7 |a antigen
|2 Other
650 _ 7 |a chronic inflammation
|2 Other
650 _ 7 |a colon cancer
|2 Other
700 1 _ |a Nikitina, Ekaterina
|0 P:(DE-He78)83275dace99f5b3d2c745bae4297121c
|b 1
|u dkfz
700 1 _ |a Chakraborty, Deblina
|0 P:(DE-He78)82d5d6ab1514b155472412825e49829e
|b 2
|u dkfz
700 1 _ |a Ernst, Claudia
|0 P:(DE-He78)e228057961cd499cd6acd0ce04076f77
|b 3
|u dkfz
700 1 _ |a Gunst, Karin
|0 P:(DE-He78)75f6c58dfab869f5993d696577e466dc
|b 4
|u dkfz
700 1 _ |a Boneva, Boyana
|0 P:(DE-He78)01ee5d5212cad52a31a3715a4df67ee9
|b 5
|u dkfz
700 1 _ |a Tessmer, Claudia
|0 P:(DE-He78)44a33c775d0e27db79f8fd9e97a99e0a
|b 6
|u dkfz
700 1 _ |a Volk, Nadine
|b 7
700 1 _ |a Brobeil, Alexander
|b 8
700 1 _ |a Weber, Achim
|b 9
700 1 _ |a Heikenwalder, Mathias
|0 P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5
|b 10
|u dkfz
700 1 _ |a zur Hausen, Harald
|0 P:(DE-He78)3f43953e63fd34eca1891c5a0d9d344c
|b 11
|u dkfz
700 1 _ |a de Villiers, Ethel-Michele
|0 0000-0003-4357-0567
|b 12
|e Last author
773 _ _ |a 10.1073/pnas.2025830118
|g Vol. 118, no. 12, p. e2025830118 -
|0 PERI:(DE-600)1461794-8
|n 12
|p e2025830118
|t Proceedings of the National Academy of Sciences of the United States of America
|v 118
|y 2021
|x 1091-6490
909 C O |o oai:inrepo02.dkfz.de:167919
|p VDB
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 0
|6 P:(DE-He78)42946c81b039c802769d91e486a4d5fb
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 1
|6 P:(DE-He78)83275dace99f5b3d2c745bae4297121c
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 2
|6 P:(DE-He78)82d5d6ab1514b155472412825e49829e
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 3
|6 P:(DE-He78)e228057961cd499cd6acd0ce04076f77
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 4
|6 P:(DE-He78)75f6c58dfab869f5993d696577e466dc
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 5
|6 P:(DE-He78)01ee5d5212cad52a31a3715a4df67ee9
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 6
|6 P:(DE-He78)44a33c775d0e27db79f8fd9e97a99e0a
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 10
|6 P:(DE-He78)66ed2d4ec9bc11d29b87ac006adf85e5
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 11
|6 P:(DE-He78)3f43953e63fd34eca1891c5a0d9d344c
910 1 _ |a Deutsches Krebsforschungszentrum
|0 I:(DE-588b)2036810-0
|k DKFZ
|b 12
|6 0000-0003-4357-0567
913 0 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF3-310
|0 G:(DE-HGF)POF3-316
|3 G:(DE-HGF)POF3
|2 G:(DE-HGF)POF3-300
|4 G:(DE-HGF)POF
|v Infections and cancer
|x 0
913 1 _ |a DE-HGF
|b Gesundheit
|l Krebsforschung
|1 G:(DE-HGF)POF4-310
|0 G:(DE-HGF)POF4-316
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Infektionen, Entzündung und Krebs
|x 0
914 1 _ |y 2021
915 _ _ |a National-Konsortium
|0 StatID:(DE-HGF)0430
|2 StatID
|d 2021-01-29
|w ger
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b P NATL ACAD SCI USA : 2019
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2021-01-29
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1060
|2 StatID
|b Current Contents - Agriculture, Biology and Environmental Sciences
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1040
|2 StatID
|b Zoological Record
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2021-01-29
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2021-01-29
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2021-01-29
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b P NATL ACAD SCI USA : 2019
|d 2021-01-29
920 1 _ |0 I:(DE-He78)F200-20160331
|k F200
|l F200 Arbeitsgruppe Episomel-Persistierende DNA in Krebs- und chron. Erkrankungen
|x 0
920 1 _ |0 I:(DE-He78)W170-20160331
|k W170
|l W170 Monoklonale Antikörper
|x 1
920 1 _ |0 I:(DE-He78)F180-20160331
|k F180
|l F180 Chronische Entzündung und Krebs
|x 2
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-He78)F200-20160331
980 _ _ |a I:(DE-He78)W170-20160331
980 _ _ |a I:(DE-He78)F180-20160331
980 _ _ |a UNRESTRICTED

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21