%0 Journal Article
%A Aredo, Jacqueline V
%A Luo, Sophia J
%A Gardner, Rebecca M
%A Sanyal, Nilotpal
%A Choi, Eunji
%A Hickey, Thomas P
%A Riley, Thomas L
%A Huang, Wen-Yi
%A Kurian, Allison W
%A Leung, Ann N
%A Wilkens, Lynne R
%A Robbins, Hilary A
%A Riboli, Elio
%A Kaaks, Rudolf
%A Tjønneland, Anne
%A Vermeulen, Roel C H
%A Panico, Salvatore
%A Le Marchand, Loïc
%A Amos, Christopher I
%A Hung, Rayjean J
%A Freedman, Neal D
%A Johansson, Mattias
%A Cheng, Iona
%A Wakelee, Heather A
%A Han, Summer S
%T Tobacco Smoking and Risk of Second Primary Lung Cancer.
%J Journal of thoracic oncology
%V 16
%N 6
%@ 1556-0864
%C Amsterdam
%I Elsevier
%M DKFZ-2021-00640
%P 968-979
%D 2021
%Z 16(6):968-979
%X Lung cancer survivors are at high risk of a second primary lung cancer (SPLC). However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. We examined risk factors for SPLC across multiple epidemiologic cohorts and assessed the impact of smoking cessation on reducing SPLC risk.We analyzed data from 7,059 participants in the Multiethnic Cohort (MEC) diagnosed with an initial primary lung cancer (IPLC) between 1993 and 2017. Cause-specific proportional hazards models estimated SPLC risk. We conducted validation studies using the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, N=3,423 IPLC cases) and European Prospective Investigation into Cancer and Nutrition (EPIC, N=4,731 IPLC cases) cohorts and pooled the SPLC risk estimates using random effects meta-analysis.Overall, 163 (2.3
%K screening (Other)
%K second primary lung cancer (Other)
%K smoking cessation (Other)
%K surveillance (Other)
%K tobacco smoking (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33722709
%R 10.1016/j.jtho.2021.02.024.
%U https://inrepo02.dkfz.de/record/167921