TY  - JOUR
AU  - Aredo, Jacqueline V
AU  - Luo, Sophia J
AU  - Gardner, Rebecca M
AU  - Sanyal, Nilotpal
AU  - Choi, Eunji
AU  - Hickey, Thomas P
AU  - Riley, Thomas L
AU  - Huang, Wen-Yi
AU  - Kurian, Allison W
AU  - Leung, Ann N
AU  - Wilkens, Lynne R
AU  - Robbins, Hilary A
AU  - Riboli, Elio
AU  - Kaaks, Rudolf
AU  - Tjønneland, Anne
AU  - Vermeulen, Roel C H
AU  - Panico, Salvatore
AU  - Le Marchand, Loïc
AU  - Amos, Christopher I
AU  - Hung, Rayjean J
AU  - Freedman, Neal D
AU  - Johansson, Mattias
AU  - Cheng, Iona
AU  - Wakelee, Heather A
AU  - Han, Summer S
TI  - Tobacco Smoking and Risk of Second Primary Lung Cancer.
JO  - Journal of thoracic oncology
VL  - 16
IS  - 6
SN  - 1556-0864
CY  - Amsterdam
PB  - Elsevier
M1  - DKFZ-2021-00640
SP  - 968-979
PY  - 2021
N1  - 16(6):968-979
AB  - Lung cancer survivors are at high risk of a second primary lung cancer (SPLC). However, SPLC risk factors have not been established and the impact of tobacco smoking remains controversial. We examined risk factors for SPLC across multiple epidemiologic cohorts and assessed the impact of smoking cessation on reducing SPLC risk.We analyzed data from 7,059 participants in the Multiethnic Cohort (MEC) diagnosed with an initial primary lung cancer (IPLC) between 1993 and 2017. Cause-specific proportional hazards models estimated SPLC risk. We conducted validation studies using the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, N=3,423 IPLC cases) and European Prospective Investigation into Cancer and Nutrition (EPIC, N=4,731 IPLC cases) cohorts and pooled the SPLC risk estimates using random effects meta-analysis.Overall, 163 (2.3
KW  - screening (Other)
KW  - second primary lung cancer (Other)
KW  - smoking cessation (Other)
KW  - surveillance (Other)
KW  - tobacco smoking (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33722709
DO  - DOI:10.1016/j.jtho.2021.02.024.
UR  - https://inrepo02.dkfz.de/record/167921
ER  -