%0 Journal Article
%A Tsilidis, Konstantinos K
%A Papadimitriou, Nikos
%A Dimou, Niki
%A Gill, Dipender
%A Lewis, Sarah J
%A Martin, Richard M
%A Murphy, Neil
%A Markozannes, Georgios
%A Zuber, Verena
%A Cross, Amanda J
%A Burrows, Kimberley
%A Lopez, David S
%A Key, Timothy J
%A Travis, Ruth C
%A Perez-Cornago, Aurora
%A Hunter, David J
%A van Duijnhoven, Fränzel J B
%A Albanes, Demetrius
%A Arndt, Volker
%A Berndt, Sonja I
%A Bézieau, Stéphane
%A Bishop, D Timothy
%A Boehm, Juergen
%A Brenner, Hermann
%A Burnett-Hartman, Andrea
%A Campbell, Peter T
%A Casey, Graham
%A Castellví-Bel, Sergi
%A Chan, Andrew T
%A Chang-Claude, Jenny
%A de la Chapelle, Albert
%A Figueiredo, Jane C
%A Gallinger, Steven J
%A Giles, Graham G
%A Goodman, Phyllis J
%A Gsur, Andrea
%A Hampe, Jochen
%A Hampel, Heather
%A Hoffmeister, Michael
%A Jenkins, Mark A
%A Keku, Temitope O
%A Kweon, Sun-Seog
%A Larsson, Susanna C
%A Le Marchand, Loic
%A Li, Christopher I
%A Li, Li
%A Lindblom, Annika
%A Martín, Vicente
%A Milne, Roger L
%A Moreno, Victor
%A Nan, Hongmei
%A Nassir, Rami
%A Newcomb, Polly A
%A Offit, Kenneth
%A Pharoah, Paul D P
%A Platz, Elizabeth A
%A Potter, John D
%A Qi, Lihong
%A Rennert, Gad
%A Sakoda, Lori C
%A Schafmayer, Clemens
%A Slattery, Martha L
%A Snetselaar, Linda
%A Schenk, Jeanette
%A Thibodeau, Stephen N
%A Ulrich, Cornelia M
%A Van Guelpen, Bethany
%A Harlid, Sophia
%A Visvanathan, Kala
%A Vodickova, Ludmila
%A Wang, Hansong
%A White, Emily
%A Wolk, Alicja
%A Woods, Michael O
%A Wu, Anna H
%A Zheng, Wei
%A Bueno-de-Mesquita, Bas
%A Boutron-Ruault, Marie-Christine
%A Hughes, David J
%A Jakszyn, Paula
%A Kühn, Tilman
%A Palli, Domenico
%A Riboli, Elio
%A Giovannucci, Edward L
%A Banbury, Barbara L
%A Gruber, Stephen B
%A Peters, Ulrike
%A Gunter, Marc J
%T Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.
%J The American journal of clinical nutrition
%V 113
%N 6
%@ 1938-3207
%C Oxford
%I Oxford University Press
%M DKFZ-2021-00667
%P 1490-1502
%D 2021
%Z 113(6):1490-1502
%X The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR).Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95
%K Mendelian randomization (Other)
%K colorectal cancer (Other)
%K genes (Other)
%K nutrition (Other)
%K supplements (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33740060
%R 10.1093/ajcn/nqab003
%U https://inrepo02.dkfz.de/record/168079