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000168079 0247_ $$2ISSN$$a1938-3215
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000168079 1001_ $$aTsilidis, Konstantinos K$$b0
000168079 245__ $$aGenetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.
000168079 260__ $$aOxford$$bOxford University Press$$c2021
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000168079 520__ $$aThe literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR).Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95% CI: 1.00, 1.17; P value = 0.05] and similarly for proximal colon cancer, and for vitamin B-12 concentration and higher risk of colorectal cancer (ORSD: 1.12; 95% CI: 1.03, 1.21; P value = 0.01) and similarly for colon cancer. A nominally significant association was also noted for genetically predicted selenium concentration and lower risk of colon cancer (ORSD: 0.98; 95% CI: 0.96, 1.00; P value = 0.05) and similarly for distal colon cancer. These associations were robust to sensitivity analyses. Nominally significant inverse associations were observed for zinc and risk of colorectal and distal colon cancers, but sensitivity analyses could not be performed. None of these findings survived correction for multiple testing. Genetically predicted concentrations of β-carotene, calcium, copper, folate, magnesium, phosphorus, and vitamin B-6 were not associated with disease risk.These results suggest possible causal associations of circulating iron and vitamin B-12 (positively) and selenium (inversely) with risk of colon cancer.
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000168079 650_7 $$2Other$$aMendelian randomization
000168079 650_7 $$2Other$$acolorectal cancer
000168079 650_7 $$2Other$$agenes
000168079 650_7 $$2Other$$anutrition
000168079 650_7 $$2Other$$asupplements
000168079 7001_ $$aPapadimitriou, Nikos$$b1
000168079 7001_ $$aDimou, Niki$$b2
000168079 7001_ $$aGill, Dipender$$b3
000168079 7001_ $$aLewis, Sarah J$$b4
000168079 7001_ $$aMartin, Richard M$$b5
000168079 7001_ $$aMurphy, Neil$$b6
000168079 7001_ $$aMarkozannes, Georgios$$b7
000168079 7001_ $$aZuber, Verena$$b8
000168079 7001_ $$aCross, Amanda J$$b9
000168079 7001_ $$aBurrows, Kimberley$$b10
000168079 7001_ $$aLopez, David S$$b11
000168079 7001_ $$aKey, Timothy J$$b12
000168079 7001_ $$aTravis, Ruth C$$b13
000168079 7001_ $$aPerez-Cornago, Aurora$$b14
000168079 7001_ $$aHunter, David J$$b15
000168079 7001_ $$avan Duijnhoven, Fränzel J B$$b16
000168079 7001_ $$aAlbanes, Demetrius$$b17
000168079 7001_ $$0P:(DE-He78)d023fdf423d87ee6c710e34dd7581fa0$$aArndt, Volker$$b18$$udkfz
000168079 7001_ $$aBerndt, Sonja I$$b19
000168079 7001_ $$aBézieau, Stéphane$$b20
000168079 7001_ $$aBishop, D Timothy$$b21
000168079 7001_ $$aBoehm, Juergen$$b22
000168079 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b23$$udkfz
000168079 7001_ $$aBurnett-Hartman, Andrea$$b24
000168079 7001_ $$aCampbell, Peter T$$b25
000168079 7001_ $$aCasey, Graham$$b26
000168079 7001_ $$aCastellví-Bel, Sergi$$b27
000168079 7001_ $$aChan, Andrew T$$b28
000168079 7001_ $$0P:(DE-He78)c259d6cc99edf5c7bc7ce22c7f87c253$$aChang-Claude, Jenny$$b29$$udkfz
000168079 7001_ $$ade la Chapelle, Albert$$b30
000168079 7001_ $$aFigueiredo, Jane C$$b31
000168079 7001_ $$aGallinger, Steven J$$b32
000168079 7001_ $$aGiles, Graham G$$b33
000168079 7001_ $$aGoodman, Phyllis J$$b34
000168079 7001_ $$aGsur, Andrea$$b35
000168079 7001_ $$aHampe, Jochen$$b36
000168079 7001_ $$aHampel, Heather$$b37
000168079 7001_ $$0P:(DE-He78)6c5d058b7552d071a7fa4c5e943fff0f$$aHoffmeister, Michael$$b38$$udkfz
000168079 7001_ $$aJenkins, Mark A$$b39
000168079 7001_ $$aKeku, Temitope O$$b40
000168079 7001_ $$aKweon, Sun-Seog$$b41
000168079 7001_ $$aLarsson, Susanna C$$b42
000168079 7001_ $$aLe Marchand, Loic$$b43
000168079 7001_ $$aLi, Christopher I$$b44
000168079 7001_ $$aLi, Li$$b45
000168079 7001_ $$aLindblom, Annika$$b46
000168079 7001_ $$aMartín, Vicente$$b47
000168079 7001_ $$aMilne, Roger L$$b48
000168079 7001_ $$aMoreno, Victor$$b49
000168079 7001_ $$aNan, Hongmei$$b50
000168079 7001_ $$aNassir, Rami$$b51
000168079 7001_ $$aNewcomb, Polly A$$b52
000168079 7001_ $$aOffit, Kenneth$$b53
000168079 7001_ $$aPharoah, Paul D P$$b54
000168079 7001_ $$aPlatz, Elizabeth A$$b55
000168079 7001_ $$aPotter, John D$$b56
000168079 7001_ $$aQi, Lihong$$b57
000168079 7001_ $$aRennert, Gad$$b58
000168079 7001_ $$aSakoda, Lori C$$b59
000168079 7001_ $$aSchafmayer, Clemens$$b60
000168079 7001_ $$aSlattery, Martha L$$b61
000168079 7001_ $$aSnetselaar, Linda$$b62
000168079 7001_ $$aSchenk, Jeanette$$b63
000168079 7001_ $$aThibodeau, Stephen N$$b64
000168079 7001_ $$aUlrich, Cornelia M$$b65
000168079 7001_ $$aVan Guelpen, Bethany$$b66
000168079 7001_ $$aHarlid, Sophia$$b67
000168079 7001_ $$aVisvanathan, Kala$$b68
000168079 7001_ $$aVodickova, Ludmila$$b69
000168079 7001_ $$aWang, Hansong$$b70
000168079 7001_ $$aWhite, Emily$$b71
000168079 7001_ $$aWolk, Alicja$$b72
000168079 7001_ $$aWoods, Michael O$$b73
000168079 7001_ $$aWu, Anna H$$b74
000168079 7001_ $$aZheng, Wei$$b75
000168079 7001_ $$aBueno-de-Mesquita, Bas$$b76
000168079 7001_ $$aBoutron-Ruault, Marie-Christine$$b77
000168079 7001_ $$aHughes, David J$$b78
000168079 7001_ $$aJakszyn, Paula$$b79
000168079 7001_ $$0P:(DE-He78)0907a10ba1dc8f53f04907f54f6fdcfe$$aKühn, Tilman$$b80$$udkfz
000168079 7001_ $$aPalli, Domenico$$b81
000168079 7001_ $$aRiboli, Elio$$b82
000168079 7001_ $$aGiovannucci, Edward L$$b83
000168079 7001_ $$aBanbury, Barbara L$$b84
000168079 7001_ $$aGruber, Stephen B$$b85
000168079 7001_ $$aPeters, Ulrike$$b86
000168079 7001_ $$aGunter, Marc J$$b87
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