TY  - JOUR
AU  - Tsilidis, Konstantinos K
AU  - Papadimitriou, Nikos
AU  - Dimou, Niki
AU  - Gill, Dipender
AU  - Lewis, Sarah J
AU  - Martin, Richard M
AU  - Murphy, Neil
AU  - Markozannes, Georgios
AU  - Zuber, Verena
AU  - Cross, Amanda J
AU  - Burrows, Kimberley
AU  - Lopez, David S
AU  - Key, Timothy J
AU  - Travis, Ruth C
AU  - Perez-Cornago, Aurora
AU  - Hunter, David J
AU  - van Duijnhoven, Fränzel J B
AU  - Albanes, Demetrius
AU  - Arndt, Volker
AU  - Berndt, Sonja I
AU  - Bézieau, Stéphane
AU  - Bishop, D Timothy
AU  - Boehm, Juergen
AU  - Brenner, Hermann
AU  - Burnett-Hartman, Andrea
AU  - Campbell, Peter T
AU  - Casey, Graham
AU  - Castellví-Bel, Sergi
AU  - Chan, Andrew T
AU  - Chang-Claude, Jenny
AU  - de la Chapelle, Albert
AU  - Figueiredo, Jane C
AU  - Gallinger, Steven J
AU  - Giles, Graham G
AU  - Goodman, Phyllis J
AU  - Gsur, Andrea
AU  - Hampe, Jochen
AU  - Hampel, Heather
AU  - Hoffmeister, Michael
AU  - Jenkins, Mark A
AU  - Keku, Temitope O
AU  - Kweon, Sun-Seog
AU  - Larsson, Susanna C
AU  - Le Marchand, Loic
AU  - Li, Christopher I
AU  - Li, Li
AU  - Lindblom, Annika
AU  - Martín, Vicente
AU  - Milne, Roger L
AU  - Moreno, Victor
AU  - Nan, Hongmei
AU  - Nassir, Rami
AU  - Newcomb, Polly A
AU  - Offit, Kenneth
AU  - Pharoah, Paul D P
AU  - Platz, Elizabeth A
AU  - Potter, John D
AU  - Qi, Lihong
AU  - Rennert, Gad
AU  - Sakoda, Lori C
AU  - Schafmayer, Clemens
AU  - Slattery, Martha L
AU  - Snetselaar, Linda
AU  - Schenk, Jeanette
AU  - Thibodeau, Stephen N
AU  - Ulrich, Cornelia M
AU  - Van Guelpen, Bethany
AU  - Harlid, Sophia
AU  - Visvanathan, Kala
AU  - Vodickova, Ludmila
AU  - Wang, Hansong
AU  - White, Emily
AU  - Wolk, Alicja
AU  - Woods, Michael O
AU  - Wu, Anna H
AU  - Zheng, Wei
AU  - Bueno-de-Mesquita, Bas
AU  - Boutron-Ruault, Marie-Christine
AU  - Hughes, David J
AU  - Jakszyn, Paula
AU  - Kühn, Tilman
AU  - Palli, Domenico
AU  - Riboli, Elio
AU  - Giovannucci, Edward L
AU  - Banbury, Barbara L
AU  - Gruber, Stephen B
AU  - Peters, Ulrike
AU  - Gunter, Marc J
TI  - Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study.
JO  - The American journal of clinical nutrition
VL  - 113
IS  - 6
SN  - 1938-3207
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2021-00667
SP  - 1490-1502
PY  - 2021
N1  - 113(6):1490-1502
AB  - The literature on associations of circulating concentrations of minerals and vitamins with risk of colorectal cancer is limited and inconsistent. Evidence from randomized controlled trials (RCTs) to support the efficacy of dietary modification or nutrient supplementation for colorectal cancer prevention is also limited.To complement observational and RCT findings, we investigated associations of genetically predicted concentrations of 11 micronutrients (β-carotene, calcium, copper, folate, iron, magnesium, phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc) with colorectal cancer risk using Mendelian randomization (MR).Two-sample MR was conducted using 58,221 individuals with colorectal cancer and 67,694 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry. Inverse variance-weighted MR analyses were performed with sensitivity analyses to assess the impact of potential violations of MR assumptions.Nominally significant associations were noted for genetically predicted iron concentration and higher risk of colon cancer [ORs per SD (ORSD): 1.08; 95
KW  - Mendelian randomization (Other)
KW  - colorectal cancer (Other)
KW  - genes (Other)
KW  - nutrition (Other)
KW  - supplements (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33740060
DO  - DOI:10.1093/ajcn/nqab003
UR  - https://inrepo02.dkfz.de/record/168079
ER  -