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@ARTICLE{Tsilidis:168079,
      author       = {K. K. Tsilidis and N. Papadimitriou and N. Dimou and D.
                      Gill and S. J. Lewis and R. M. Martin and N. Murphy and G.
                      Markozannes and V. Zuber and A. J. Cross and K. Burrows and
                      D. S. Lopez and T. J. Key and R. C. Travis and A.
                      Perez-Cornago and D. J. Hunter and F. J. B. van Duijnhoven
                      and D. Albanes and V. Arndt$^*$ and S. I. Berndt and S.
                      Bézieau and D. T. Bishop and J. Boehm and H. Brenner$^*$
                      and A. Burnett-Hartman and P. T. Campbell and G. Casey and
                      S. Castellví-Bel and A. T. Chan and J. Chang-Claude$^*$ and
                      A. de la Chapelle and J. C. Figueiredo and S. J. Gallinger
                      and G. G. Giles and P. J. Goodman and A. Gsur and J. Hampe
                      and H. Hampel and M. Hoffmeister$^*$ and M. A. Jenkins and
                      T. O. Keku and S.-S. Kweon and S. C. Larsson and L. Le
                      Marchand and C. I. Li and L. Li and A. Lindblom and V.
                      Martín and R. L. Milne and V. Moreno and H. Nan and R.
                      Nassir and P. A. Newcomb and K. Offit and P. D. P. Pharoah
                      and E. A. Platz and J. D. Potter and L. Qi and G. Rennert
                      and L. C. Sakoda and C. Schafmayer and M. L. Slattery and L.
                      Snetselaar and J. Schenk and S. N. Thibodeau and C. M.
                      Ulrich and B. Van Guelpen and S. Harlid and K. Visvanathan
                      and L. Vodickova and H. Wang and E. White and A. Wolk and M.
                      O. Woods and A. H. Wu and W. Zheng and B. Bueno-de-Mesquita
                      and M.-C. Boutron-Ruault and D. J. Hughes and P. Jakszyn and
                      T. Kühn$^*$ and D. Palli and E. Riboli and E. L.
                      Giovannucci and B. L. Banbury and S. B. Gruber and U. Peters
                      and M. J. Gunter},
      title        = {{G}enetically predicted circulating concentrations of
                      micronutrients and risk of colorectal cancer among
                      individuals of {E}uropean descent: a {M}endelian
                      randomization study.},
      journal      = {The American journal of clinical nutrition},
      volume       = {113},
      number       = {6},
      issn         = {1938-3207},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-00667},
      pages        = {1490-1502},
      year         = {2021},
      note         = {113(6):1490-1502},
      abstract     = {The literature on associations of circulating
                      concentrations of minerals and vitamins with risk of
                      colorectal cancer is limited and inconsistent. Evidence from
                      randomized controlled trials (RCTs) to support the efficacy
                      of dietary modification or nutrient supplementation for
                      colorectal cancer prevention is also limited.To complement
                      observational and RCT findings, we investigated associations
                      of genetically predicted concentrations of 11 micronutrients
                      (β-carotene, calcium, copper, folate, iron, magnesium,
                      phosphorus, selenium, vitamin B-6, vitamin B-12, and zinc)
                      with colorectal cancer risk using Mendelian randomization
                      (MR).Two-sample MR was conducted using 58,221 individuals
                      with colorectal cancer and 67,694 controls from the Genetics
                      and Epidemiology of Colorectal Cancer Consortium, Colorectal
                      Cancer Transdisciplinary Study, and Colon Cancer Family
                      Registry. Inverse variance-weighted MR analyses were
                      performed with sensitivity analyses to assess the impact of
                      potential violations of MR assumptions.Nominally significant
                      associations were noted for genetically predicted iron
                      concentration and higher risk of colon cancer [ORs per SD
                      (ORSD): 1.08; $95\%$ CI: 1.00, 1.17; P value = 0.05] and
                      similarly for proximal colon cancer, and for vitamin B-12
                      concentration and higher risk of colorectal cancer (ORSD:
                      1.12; $95\%$ CI: 1.03, 1.21; P value = 0.01) and similarly
                      for colon cancer. A nominally significant association was
                      also noted for genetically predicted selenium concentration
                      and lower risk of colon cancer (ORSD: 0.98; $95\%$ CI: 0.96,
                      1.00; P value = 0.05) and similarly for distal colon cancer.
                      These associations were robust to sensitivity analyses.
                      Nominally significant inverse associations were observed for
                      zinc and risk of colorectal and distal colon cancers, but
                      sensitivity analyses could not be performed. None of these
                      findings survived correction for multiple testing.
                      Genetically predicted concentrations of β-carotene,
                      calcium, copper, folate, magnesium, phosphorus, and vitamin
                      B-6 were not associated with disease risk.These results
                      suggest possible causal associations of circulating iron and
                      vitamin B-12 (positively) and selenium (inversely) with risk
                      of colon cancer.},
      keywords     = {Mendelian randomization (Other) / colorectal cancer (Other)
                      / genes (Other) / nutrition (Other) / supplements (Other)},
      cin          = {C070 / C120 / HD01 / C020},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33740060},
      doi          = {10.1093/ajcn/nqab003},
      url          = {https://inrepo02.dkfz.de/record/168079},
}