%0 Journal Article
%A Boakye, Daniel
%A Jansen, Lina
%A Schöttker, Ben
%A Jansen, Eugene H J M
%A Halama, Niels
%A Maalmi, Haifa
%A Gao, Xin
%A Chang-Claude, Jenny
%A Hoffmeister, Michael
%A Brenner, Hermann
%T The association of vitamin D with survival in colorectal cancer patients depends on antioxidant capacity.
%J The American journal of clinical nutrition
%V 113
%N 6
%@ 1938-3207
%C Oxford
%I Oxford University Press
%M DKFZ-2021-00668
%P 1458-1467
%D 2021
%Z #EA:C070#LA:C070# / 113(6):1458-1467
%X Vitamin D plays a role in detoxifying free radicals, which might explain the previously reported lower mortality in colorectal cancer (CRC) patients with higher vitamin D concentrations.We aimed to assess whether the associations of 25-hydroxyvitamin D [25(OH)D] with prognosis in CRC patients differ by total thiol concentration (TTC), a biomarker of antioxidant capacity.CRC patients who were diagnosed from 2003 to 2010 and recruited into a population-based study in southern Germany (n = 2,592) were followed over a period of 6 y. 25(OH)D and TTC were evaluated from blood samples collected shortly after CRC diagnosis. Associations of 25(OH)D with all-cause and CRC mortality according to TTC were estimated using multivariable Cox proportional hazards regression.There was a weak positive correlation between 25(OH)D and TTC (r = 0.26, P < 0.001). 25(OH)D was inversely associated with mortality among patients in the lowest and middle TTC tertiles, but no associations were found among patients in the highest TTC tertile (P-interaction = 0.01). Among patients in the lowest/middle TTC tertiles, those in the middle and highest (compared with lowest) 25(OH)D tertiles had 31
%K 25(OH)D (Other)
%K antioxidant capacity (Other)
%K colorectal cancer (Other)
%K survival (Other)
%K total thiol (Other)
%K vitamin D (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:33740035
%R 10.1093/ajcn/nqaa405
%U https://inrepo02.dkfz.de/record/168080