TY  - JOUR
AU  - Boakye, Daniel
AU  - Jansen, Lina
AU  - Schöttker, Ben
AU  - Jansen, Eugene H J M
AU  - Halama, Niels
AU  - Maalmi, Haifa
AU  - Gao, Xin
AU  - Chang-Claude, Jenny
AU  - Hoffmeister, Michael
AU  - Brenner, Hermann
TI  - The association of vitamin D with survival in colorectal cancer patients depends on antioxidant capacity.
JO  - The American journal of clinical nutrition
VL  - 113
IS  - 6
SN  - 1938-3207
CY  - Oxford
PB  - Oxford University Press
M1  - DKFZ-2021-00668
SP  - 1458-1467
PY  - 2021
N1  - #EA:C070#LA:C070# / 113(6):1458-1467
AB  - Vitamin D plays a role in detoxifying free radicals, which might explain the previously reported lower mortality in colorectal cancer (CRC) patients with higher vitamin D concentrations.We aimed to assess whether the associations of 25-hydroxyvitamin D [25(OH)D] with prognosis in CRC patients differ by total thiol concentration (TTC), a biomarker of antioxidant capacity.CRC patients who were diagnosed from 2003 to 2010 and recruited into a population-based study in southern Germany (n = 2,592) were followed over a period of 6 y. 25(OH)D and TTC were evaluated from blood samples collected shortly after CRC diagnosis. Associations of 25(OH)D with all-cause and CRC mortality according to TTC were estimated using multivariable Cox proportional hazards regression.There was a weak positive correlation between 25(OH)D and TTC (r = 0.26, P < 0.001). 25(OH)D was inversely associated with mortality among patients in the lowest and middle TTC tertiles, but no associations were found among patients in the highest TTC tertile (P-interaction = 0.01). Among patients in the lowest/middle TTC tertiles, those in the middle and highest (compared with lowest) 25(OH)D tertiles had 31
KW  - 25(OH)D (Other)
KW  - antioxidant capacity (Other)
KW  - colorectal cancer (Other)
KW  - survival (Other)
KW  - total thiol (Other)
KW  - vitamin D (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:33740035
DO  - DOI:10.1093/ajcn/nqaa405
UR  - https://inrepo02.dkfz.de/record/168080
ER  -