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@ARTICLE{Boakye:168080,
      author       = {D. Boakye$^*$ and L. Jansen$^*$ and B. Schöttker$^*$ and
                      E. H. J. M. Jansen and N. Halama$^*$ and H. Maalmi$^*$ and
                      X. Gao$^*$ and J. Chang-Claude$^*$ and M. Hoffmeister$^*$
                      and H. Brenner$^*$},
      title        = {{T}he association of vitamin {D} with survival in
                      colorectal cancer patients depends on antioxidant capacity.},
      journal      = {The American journal of clinical nutrition},
      volume       = {113},
      number       = {6},
      issn         = {1938-3207},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {DKFZ-2021-00668},
      pages        = {1458-1467},
      year         = {2021},
      note         = {#EA:C070#LA:C070# / 113(6):1458-1467},
      abstract     = {Vitamin D plays a role in detoxifying free radicals, which
                      might explain the previously reported lower mortality in
                      colorectal cancer (CRC) patients with higher vitamin D
                      concentrations.We aimed to assess whether the associations
                      of 25-hydroxyvitamin D [25(OH)D] with prognosis in CRC
                      patients differ by total thiol concentration (TTC), a
                      biomarker of antioxidant capacity.CRC patients who were
                      diagnosed from 2003 to 2010 and recruited into a
                      population-based study in southern Germany (n = 2,592)
                      were followed over a period of 6 y. 25(OH)D and TTC were
                      evaluated from blood samples collected shortly after CRC
                      diagnosis. Associations of 25(OH)D with all-cause and CRC
                      mortality according to TTC were estimated using
                      multivariable Cox proportional hazards regression.There was
                      a weak positive correlation between 25(OH)D and TTC
                      (r = 0.26, P < 0.001). 25(OH)D was inversely associated
                      with mortality among patients in the lowest and middle TTC
                      tertiles, but no associations were found among patients in
                      the highest TTC tertile (P-interaction = 0.01). Among
                      patients in the lowest/middle TTC tertiles, those in the
                      middle and highest (compared with lowest) 25(OH)D tertiles
                      had $31\%$ and $44\%$ lower all-cause mortality
                      (P < 0.001) and $25\%$ and $45\%$ lower CRC mortality
                      (P < 0.001), respectively. However, in the highest TTC
                      tertile, 25(OH)D was not associated with all-cause
                      (P = 0.638) or CRC mortality (P = 0.395).The survival
                      advantages in CRC patients with adequate vitamin D strongly
                      depend on antioxidant capacity and are most pronounced in
                      cases of low antioxidant capacity. These findings suggest
                      that TTC and other biomarkers of antioxidant status may be
                      useful as the basis for enhanced selection criteria of
                      patients for vitamin D supplementation, in addition to the
                      conventional judgment based on blood 25(OH)D concentrations,
                      and also for refining selection of patients for clinical
                      trials aiming to estimate the effect of vitamin D
                      supplementation.},
      keywords     = {25(OH)D (Other) / antioxidant capacity (Other) / colorectal
                      cancer (Other) / survival (Other) / total thiol (Other) /
                      vitamin D (Other)},
      cin          = {C070 / D240 / C020 / C120},
      ddc          = {570},
      cid          = {I:(DE-He78)C070-20160331 / I:(DE-He78)D240-20160331 /
                      I:(DE-He78)C020-20160331 / I:(DE-He78)C120-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:33740035},
      doi          = {10.1093/ajcn/nqaa405},
      url          = {https://inrepo02.dkfz.de/record/168080},
}